Pliszka S R, Rogeness G A, Medrano M A
Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284-7792.
Psychiatry Res. 1988 Apr;24(1):35-44. doi: 10.1016/0165-1781(88)90137-0.
Plasma 3-methoxy-4-hydroxyphenylglycol (MHPG), plasma dopamine-beta-hydroxylase (DBH) activity, and platelet monoamine oxidase (MAO) were obtained in 42 boys (7-14 years old) consecutively evaluated at a community mental health clinic. The boys were diagnosed according to DSM-III criteria by a child psychiatrist using a semistructured interview with the parent and child. The Revised Behavior Problem Checklist (RBPC) and the Revised Children's Manifest Anxiety Scale (RCMAS) were consecutively obtained on the last 24 subjects. No relationship of any of the plasma measures was found with respect to the DSM-III diagnoses. Plasma MHPG was positively correlated with the parent's rating of the child's anxiety on the Anxiety-Withdrawal factor of the RBPC. Plasma MHPG as well as platelet MAO activity, correlated positively with the child's self-rating of anxiety on the RCMAS. Children classified by the RBPC as having high conduct symptoms and low anxiety symptoms had significantly lower plasma MHPG than those subjects with low conduct problems and high anxiety. Platelet MAO activity was found to be negatively correlated to the child's score on the Lie Scale of the RCMAS.
在一家社区心理健康诊所，对42名年龄在7至14岁的男孩进行了连续评估，检测了他们血浆中的3-甲氧基-4-羟苯乙二醇（MHPG）、血浆多巴胺-β-羟化酶（DBH）活性以及血小板单胺氧化酶（MAO）。这些男孩由一名儿童精神科医生根据《精神疾病诊断与统计手册》第三版（DSM-III）标准，通过对家长和孩子进行半结构化访谈来进行诊断。对最后24名受试者连续获取了修订版行为问题清单（RBPC）和修订版儿童显性焦虑量表（RCMAS）。未发现任何血浆检测指标与DSM-III诊断之间存在关联。血浆MHPG与家长在RBPC焦虑-退缩因子上对孩子焦虑程度的评分呈正相关。血浆MHPG以及血小板MAO活性与孩子在RCMAS上的焦虑自评呈正相关。根据RBPC分类，具有高行为症状和低焦虑症状的儿童，其血浆MHPG显著低于那些具有低行为问题和高焦虑的受试者。发现血小板MAO活性与孩子在RCMAS说谎量表上的得分呈负相关。
