Denha Eric, Rahim Ali, Modi Sunjay, Oyibo Oghenekpaobor, Scott Megan
Internal Medicine, Henry Ford Health System, Detroit, USA.
Anaesthesiology, Henry Ford Health System, Detroit, USA.
Cureus. 2021 Mar 29;13(3):e14165. doi: 10.7759/cureus.14165.
Immunoglobulin A (IgA) nephropathy, mesangial deposition of IgA in renal parenchyma, typically presents with hematuria and proteinuria. Leukocytoclastic vasculitis (LCV), a small-vessel vasculitis, can present secondary to IgA. We will discuss a case of secondary IgA nephropathy with concomitant LCV in a patient with reactivated hepatitis C. A 55-year-old male with decompensated alcoholic cirrhosis presented for a bilateral lower-extremity rash. The patient was diagnosed with IgA nephropathy, by kidney biopsy, and skin biopsy showing LCV. Further investigation revealed hepatitis C viral load was 275,000. We present a rare presentation of secondary IgA nephropathy with concomitant LCV, which we hypothesize was secondary to reactivation of hepatitis C.
免疫球蛋白A(IgA)肾病,即IgA在肾实质中的系膜沉积,通常表现为血尿和蛋白尿。白细胞破碎性血管炎(LCV)是一种小血管炎,可继发于IgA。我们将讨论一例丙型肝炎复发患者继发IgA肾病合并LCV的病例。一名55岁男性,患有失代偿性酒精性肝硬化,因双侧下肢皮疹前来就诊。经肾活检诊断为IgA肾病,皮肤活检显示为LCV。进一步检查发现丙型肝炎病毒载量为275,000。我们报告了一例罕见的继发IgA肾病合并LCV的病例,我们推测这是丙型肝炎复发所致。