Kamoi K, Kaneko K, Matsunaga K, Yamazaki M, Murayama S, Sato T
Department of Medicine, Nagaoka Red Cross Hospital, Niigata-Pref., Japan.
Radioisotopes. 1988 Feb;37(2):95-8. doi: 10.3769/radioisotopes.37.2_95.
To clarify clinical evaluation of highly sensitive thyroid stimulating hormone (TSH) immunoradiometric assay (IRMA) using RIABEAD II kit, we measured serum TSH and its changes after TRH test in normal subjects and patients with hyper- or hypothyroidism due to Grave's disease, TSH-producing pituitary adenoma and chronic thyroiditis or Refetoff's syndrome. In 12 normals, basal TSH (0.23-1.85 microIU/ml) increased in 2.29-18.85 microIU/ml 30 min after TRH test. In patients whose serum TSH and thyroid hormone showed less than 0.10 microIU/ml and more than normal level, respectively, no response of TSH to TRH was observed, while in patients whose serum TSH and thyroid hormone showed more than 3.5 microIU/ml and less than normal level, respectively, hyperresponse of TSH to TRH was observed. In patients with hyper- or hypothyroidism, changes in serum TSH after treatment were normalized a few months later after normalizing of thyroid hormone. In patients with TSH-producing pituitary tumor or Refetoff's syndrome, serum TSH increased. These results show that serum TSH using IRMA-(RIABEAD II) kit indicates a precise function of pituitary TSH.
为阐明使用RIABEAD II试剂盒的高敏促甲状腺激素（TSH）免疫放射分析（IRMA）的临床评估，我们测定了正常受试者以及患有格雷夫斯病、促甲状腺素分泌型垂体腺瘤、慢性甲状腺炎或雷夫托夫综合征所致甲状腺功能亢进或减退患者的血清TSH及其TRH试验后的变化。12名正常受试者中，基础TSH（0.23 - 1.85微国际单位/毫升）在TRH试验后30分钟升至2.29 - 18.85微国际单位/毫升。血清TSH和甲状腺激素分别低于0.10微国际单位/毫升和高于正常水平的患者，未观察到TSH对TRH的反应，而血清TSH和甲状腺激素分别高于3.5微国际单位/毫升和低于正常水平的患者，观察到TSH对TRH的高反应。甲状腺功能亢进或减退患者治疗后，血清TSH变化在甲状腺激素正常化数月后恢复正常。促甲状腺素分泌型垂体瘤或雷夫托夫综合征患者血清TSH升高。这些结果表明，使用IRMA -（RIABEAD II）试剂盒测定的血清TSH可准确反映垂体TSH的功能。
