Espinosa José, Ferreras M Carmen, García David, Vallejo Raquel, Pérez Valentín
Departamento de Sanidad Animal, Facultad de Veterinaria, Instituto de Ganadería de Montaña (CSIC-ULE), Universidad de León, León, Spain.
Falco Iberia S.L., León, Spain.
Front Vet Sci. 2021 Apr 14;8:662157. doi: 10.3389/fvets.2021.662157. eCollection 2021.
A 12-year-old female peregrine falcon () from a private raptor breeding facility that presented a good body condition, died suddenly without showing previous symptoms. At necropsy, in the coelomic cavity, multiple cystic structures demarcated by a thin transparent wall and filled with a serous content were observed. They were firmly adhered to the cranial part of the epicardium and adjacent tissues and occupied the entire thoracic area of the coelomic cavity. Microscopically, emerging simultaneously from several areas the epicardium, multiple irregular channels and cystic spaces, lined by a single endothelial cell layer and separated by fibrovascular septa containing smooth muscle tissue, were observed. Immunohistochemical examination revealed that the neoplastic endothelial cells positively immunolabelled for the pan-endothelial marker factor VIII-related antigen but immunostained negative for cytokeratins (PCK26) while strong positivity for sarcomeric α-smooth muscle actin (α-SMA) was detected in the cystic walls. Based on the morphological and immunohistochemical findings, lesions were determined as consistent with a multiple cavernous pericardial lymphangioma, or pericardial lymphangiomatosis, a rare vascular neoplasm. The animal also showed a diffuse chronic perihepatitis, a necrotic area in the liver and foci of cartilaginous metaplasia and calcification in the aorta and vena cava. Literature review, particularly on the epidemiology of lymphangioma, demonstrated the rarity of this tumor in the different animal species and in this location, particularly in birds, being the first report of this type of tumor in a peregrine falcon.
一只来自私人猛禽繁育机构、身体状况良好的12岁雌性矛隼突然死亡，此前未表现出任何症状。尸检时，在体腔中观察到多个囊性结构，其由薄的透明壁界定，内部充满浆液性内容物。它们牢固地附着于心外膜的头侧部分和相邻组织，并占据了体腔的整个胸部区域。显微镜下，在心外膜的多个区域同时出现了多个不规则的通道和囊性间隙，由单层内皮细胞排列，被含有平滑肌组织的纤维血管间隔分隔。免疫组织化学检查显示，肿瘤性内皮细胞对泛内皮标记物因子VIII相关抗原呈阳性免疫标记，但对细胞角蛋白（PCK26）呈阴性免疫染色，而在囊性壁中检测到肌节α平滑肌肌动蛋白（α-SMA）呈强阳性。根据形态学和免疫组织化学结果，病变被确定为符合多发性海绵状心包淋巴管瘤，或心包淋巴管瘤病，一种罕见的血管肿瘤。该动物还表现出弥漫性慢性肝周炎、肝脏中的坏死区域以及主动脉和腔静脉中的软骨化生和钙化灶。文献综述，特别是关于淋巴管瘤的流行病学，表明这种肿瘤在不同动物物种以及在这个部位都很罕见，尤其是在鸟类中，这是这种类型肿瘤在矛隼中的首次报道。
