Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Institute of Hematology, Zhejiang University, Hangzhou, China.
J Leukoc Biol. 2021 Aug;110(2):239-255. doi: 10.1002/JLB.1MR0321-601RR. Epub 2021 May 3.
Follicular regulatory T (Tfr) cells are recently found to be a special subgroup of regulatory T (Treg) cells. Tfr cells play an important role in regulating the germinal center (GC) response, especially modulating follicular helper T (Tfh) cells and GC-B cells, thereby affecting the production of antibodies. Tfr cells are involved in the generation and development of many immune-related and inflammatory diseases. This article summarizes the advances in several aspects of Tfr cell biology, with special focus on definition and phenotype, development and differentiation, regulatory factors, functions, and interactions with T/B cells and molecules involved in performance and regulation of Tfr function. Finally, we highlight the current understanding of Tfr cells involvement in autoimmunity and alloreactivity, and describe some drugs targeting Tfr cells. These latest studies have answered some basic questions in Tfr cell biology and explored the roles of Tfr cells in immune-mediated diseases.
滤泡调节性 T（Tfr）细胞最近被发现是调节性 T（Treg）细胞的一个特殊亚群。Tfr 细胞在调节生发中心（GC）反应中起着重要作用，特别是调节滤泡辅助性 T（Tfh）细胞和 GC-B 细胞，从而影响抗体的产生。Tfr 细胞参与了许多与免疫和炎症相关疾病的发生和发展。本文总结了 Tfr 细胞生物学的几个方面的进展，特别关注 Tfr 细胞的定义和表型、发育和分化、调节因子、功能以及与 T/B 细胞的相互作用和影响 Tfr 功能的分子。最后，我们强调了目前对 Tfr 细胞参与自身免疫和同种异体反应的认识，并描述了一些针对 Tfr 细胞的药物。这些最新的研究回答了 Tfr 细胞生物学中的一些基本问题，并探讨了 Tfr 细胞在免疫介导性疾病中的作用。
