Laboratoire MIVEGEC (UMR CNRS 5290, IRD 224, UM), Montpellier, France.
Institut de Recherche Pour Le Développement, 911 Avenue Agropolis, BP 64501, 34394, Montpellier cedex 5, France.
Immunol Res. 2021 Jun;69(3):255-263. doi: 10.1007/s12026-021-09196-2. Epub 2021 Apr 30.
Human papillomaviruses (HPVs) are oncogenic viruses causing most cervical cancers. Highly prevalent in young, sexually active women, only a minority of HPV infections persist. To better characterize the immuno-modulatory impact of early HPV infections, we measured changes in a panel of 20 cytokines in cervicovaginal samples collected from young women who were tested for HPV and self-reported for genital inflammation and infection symptoms. Multi-factor statistical analyses revealed that increased IL-1Alpha and IL-12/IL-23p40 concentrations were associated with HPV infection and that macrophage inflammatory proteins were associated in particular with high-risk HPV infections. ClinicalTrials.gov identifier NCT02946346.
人乳头瘤病毒（HPV）是致癌病毒，可导致大多数宫颈癌。HPV 在年轻、性活跃的女性中高度流行，只有少数 HPV 感染持续存在。为了更好地描述早期 HPV 感染的免疫调节影响，我们测量了来自年轻女性的宫颈阴道样本中 20 种细胞因子的变化，这些女性接受了 HPV 检测，并自我报告了生殖器炎症和感染症状。多因素统计分析显示，IL-1Alpha 和 IL-12/IL-23p40 浓度的增加与 HPV 感染相关，而巨噬细胞炎症蛋白则与高危 HPV 感染特别相关。ClinicalTrials.gov 标识符 NCT02946346。
