Department of Pathology, Mexican Oncology Hospital, IMSS, Mexico, Mexico.
Department of Pathology, Oncosalud AUNA, Lima, Peru.
Cancer Rep (Hoboken). 2021 Dec;4(6):e1400. doi: 10.1002/cnr2.1400. Epub 2021 May 3.
The incidence of breast cancer (BC) in LMICs has increased by more than 20% within the last decade. In areas such as Latin America (LA), addressing BC at national levels evoke discussions surrounding fragmented care, limited resources, and regulatory barriers. Precision Medicine (PM), specifically companion diagnostics (CDx), links disease diagnosis and treatment for better patient outcomes. Thus, its application may aid in overcoming these barriers.
A panel of LA experts in fields related to BC and PM were provided with a series of relevant questions to address prior to a multi-day conference. Within this conference, each narrative was edited by the entire group, through numerous rounds of discussion until a consensus was achieved. The panel proposes specific, realistic recommendations for implementing CDx in BC in LA and other LMIC regions. In these recommendations, the authors strived to address all barriers to the widespread use and access mentioned previously within this manuscript.
This manuscript provides a review of the current state of CDx for BC in LA. Of most importance, the panel proposes practical and actionable recommendations for the implementation of CDx throughout the Region in order to identify the right patient at the right time for the right treatment.
在过去十年中，中低收入国家（LMICs）的乳腺癌（BC）发病率增长了 20%以上。在拉丁美洲（LA）等地区，在国家层面上解决 BC 问题引发了关于碎片化护理、资源有限和监管障碍的讨论。精准医学（PM），特别是伴随诊断（CDx），将疾病诊断和治疗联系起来，以改善患者的治疗效果。因此，它的应用可能有助于克服这些障碍。
一组在 BC 和 PM 相关领域的 LA 专家在参加为期多天的会议之前，被提供了一系列相关问题进行讨论。在这次会议上，整个小组通过多轮讨论，对每个叙述进行了编辑，直到达成共识。该小组针对在 LA 和其他中低收入国家地区实施 BC 的 CDx 提出了具体、现实的建议。在这些建议中，作者努力解决了本文件中提到的广泛使用和获得 CDx 的所有障碍。
本文综述了 LA 地区 BC 的 CDx 现状。最重要的是，该小组提出了在该地区实施 CDx 的切实可行的建议，以便在正确的时间为正确的患者提供正确的治疗。
