胎盘SLC38A4基因多态性1304 G>A和292 C>T及其与正常体重足月健康新生儿血糖>95 mg/dl的关联。
Placental SLC38A4 gene polymorphisms 1304 G > A and 292 C > T, and their association with glucose > 95 mg/dl in normal weight full-term healthy newborns.
作者信息
Galaviz-Hernández Carlos, Sosa-Macías Martha, Rodríguez-Morán Martha, Martínez-Aguilar Gerardo, Guerrero-Romero Fernando, González-Rentería Siblie M
机构信息
Academia de Genómica, Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional Unidad Durango, Instituto Politécnico Nacional, Durango, Mexico.
Unidad de Investigación Biomédica, Instituto Mexicano del Seguro Social, Durango, Mexico.
出版信息
Bol Med Hosp Infant Mex. 2021 May 3;78(3):200-206. doi: 10.24875/BMHIM.20000108.
BACKGROUND
The SLC38A4 gene encodes for the SNAT4 protein, which has been related to glucose metabolic alterations in human newborns. This study aimed to determine whether the 1304 G > A and 292 C > T polymorphisms of the SLC38A4 gene are associated with the presence of glucose levels > 95 mg/dL in normal weight full-term healthy newborns.
METHODS
We conducted a case-control study and analyzed 50 normal weight full-term healthy newborns. Groups were defined based on glucose levels: > 95 mg/dL (cases; n = 13) and < 95 mg/dL (controls; n = 37). The 1304 G > A and 292 C > T polymorphisms of the SLC38A4 gene were determined through quantitative polymerase chain reaction using placental DNA. The association between polymorphism and glucose levels > 95 mg/dL was established using multivariate logistic regression analysis.
RESULTS
No significant differences were observed either for gestational age or body weight at birth between groups. In the case group, newborns showed significantly higher homeostatic model assessment for insulin resistance than those in the control group (p < 0.0005). The odds ratio (OR) between the SLC38A4 gene 292 C > T single-nucleotide polymorphism (SNP) and glucose levels > 95 mg/dL was 7.78 (p = 0.024), whereas no significant association was found for the 1304 G > A SNP (OR 1.46; p = 0.77).
CONCLUSIONS
Our results suggest that the SLC38A4 gene 292 C > T SNP is associated with glucose levels > 95 mg/dL in normal weight full-term healthy newborns.
背景
SLC38A4基因编码SNAT4蛋白，该蛋白与人类新生儿的葡萄糖代谢改变有关。本研究旨在确定SLC38A4基因的1304 G>A和292 C>T多态性是否与正常体重足月健康新生儿血糖水平>95 mg/dL的情况相关。
方法
我们进行了一项病例对照研究，分析了50名正常体重足月健康新生儿。根据血糖水平将研究对象分为两组：血糖水平>95 mg/dL（病例组；n = 13）和血糖水平<95 mg/dL（对照组；n = 37）。使用胎盘DNA通过定量聚合酶链反应确定SLC38A4基因的1304 G>A和292 C>T多态性。采用多因素逻辑回归分析确定多态性与血糖水平>95 mg/dL之间的关联。
结果
两组之间在胎龄或出生体重方面均未观察到显著差异。病例组新生儿的胰岛素抵抗稳态模型评估值显著高于对照组（p < 0.0005）。SLC38A4基因292 C>T单核苷酸多态性（SNP）与血糖水平>95 mg/dL之间的比值比（OR）为7.78（p = 0.024），而1304 G>A SNP未发现显著关联（OR 1.46；p = 0.77）。
结论
我们的结果表明，SLC38A4基因292 C>T SNP与正常体重足月健康新生儿血糖水平>95 mg/dL有关。
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