Schmidt Hannes, Böttcher Alexandra, Gross Tilman, Schmidtko Achim
Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
Institute of Pharmacology and Clinical Pharmacy, Goethe University, Frankfurt am Main, Germany.
Br J Pharmacol. 2022 Jun;179(11):2361-2377. doi: 10.1111/bph.15514. Epub 2021 Jun 10.
Cyclic GMP (cGMP) is a second messenger that regulates numerous physiological and pathophysiological processes. In recent years, more and more studies have uncovered multiple roles of cGMP signalling pathways in the somatosensory system. Accumulating evidence suggests that cGMP regulates different cellular processes from embryonic development through to adulthood. During embryonic development, a cGMP-dependent signalling cascade in the trunk sensory system is essential for axon bifurcation, a specific form of branching of somatosensory axons. In adulthood, various cGMP signalling pathways in distinct cell populations of sensory neurons and dorsal horn neurons in the spinal cord play an important role in the processing of pain and itch. Some of the involved enzymes might serve as a target for future therapies. In this review, we summarise the knowledge regarding cGMP-dependent signalling pathways in dorsal root ganglia and the spinal cord during embryonic development and adulthood, and the potential of targeting these pathways. LINKED ARTICLES: This article is part of a themed issue on cGMP Signalling in Cell Growth and Survival. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.11/issuetoc.
环磷酸鸟苷（cGMP）是一种第二信使，可调节众多生理和病理生理过程。近年来，越来越多的研究揭示了cGMP信号通路在体感系统中的多种作用。越来越多的证据表明，cGMP调节从胚胎发育到成年期的不同细胞过程。在胚胎发育过程中，躯干感觉系统中依赖cGMP的信号级联对于轴突分支（体感轴突分支的一种特定形式）至关重要。在成年期，感觉神经元和脊髓背角神经元不同细胞群中的各种cGMP信号通路在疼痛和瘙痒的处理中发挥重要作用。一些相关酶可能成为未来治疗的靶点。在本综述中，我们总结了关于胚胎发育和成年期背根神经节和脊髓中依赖cGMP的信号通路的知识，以及靶向这些通路的潜力。相关文章：本文是关于细胞生长和存活中cGMP信号传导的主题问题的一部分。要查看本节中的其他文章，请访问http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.11/issuetoc。
