Neurology, Christian Medial College Vellore, India.
Virology, Christian Medical College Vellore, India.
J Neuroimmunol. 2021 Jul 15;356:577581. doi: 10.1016/j.jneuroim.2021.577581. Epub 2021 Apr 22.
Neuromyelitis optica spectrum disorders (NMOSD) are characterised by pathological antibodies to aquaporin-4 water channels of astrocytes, resulting in severe brain and spinal cord injury. Serological evidence suggests that Epstein-Barr virus (EBV) reactivation may contribute to their pathogenesis. We describe an unusual case of a woman with fever, rash and headache preceding an Aquaporin-4 antibody positive longitudinally extensive transverse myelitis. EBV was detected in her cerebrospinal fluid by polymerase chain reaction assay. This case highlights the potential role of EBV in the pathogenesis of NMOSD.
视神经脊髓炎谱系疾病（NMOSD）的特征是存在针对星形胶质细胞水通道蛋白-4 的病理性抗体，从而导致严重的脑和脊髓损伤。血清学证据表明，EB 病毒（EBV）再激活可能有助于其发病机制。我们描述了一例不常见的病例，一名女性在出现 AQP4 抗体阳性的横贯性脊髓炎之前出现发热、皮疹和头痛。聚合酶链反应检测到 EBV 存在于她的脑脊液中。该病例提示 EBV 在 NMOSD 的发病机制中可能起作用。
