Department of Biological Chemistry and Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Department of Biological Chemistry and Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Curr Opin Neurobiol. 2021 Jun;68:124-136. doi: 10.1016/j.conb.2021.02.008. Epub 2021 Apr 30.
The medial amygdala (MeA) is critical for the expression of a broad range of social behaviors, and is also connected to many other brain regions that mediate those same behaviors. Here, we summarize recent advances toward elucidating mechanisms that enable the MeA to regulate a diversity of social behaviors, and also consider what role the MeA plays within the broader network of regions that orchestrate social sensorimotor transformations. We outline the molecular, anatomical, and electrophysiological features of the MeA that segregate distinct social behaviors, propose experimental strategies to disambiguate sensory representations from behavioral function in the context of a social interaction, and consider to what extent MeA function may overlap with other regions mediating similar behaviors.
内侧杏仁核(MeA)对于广泛的社会行为表达至关重要,并且还与许多其他介导这些相同行为的大脑区域相连。在这里,我们总结了最近在阐明使 MeA 能够调节各种社会行为的机制方面的进展,同时还考虑了 MeA 在协调社会感觉运动转换的更广泛区域网络中所扮演的角色。我们概述了 MeA 的分子、解剖和电生理特征,这些特征将不同的社会行为分开,提出了在社会互动背景下从行为功能中区分感觉表示的实验策略,并考虑了 MeA 功能在多大程度上可能与其他介导类似行为的区域重叠。