Koren Yael, Lubetzky Ronit, Mandel Dror, Ovental Amit, Deutsch Varda, Hadanny Amir, Moran-Lev Hadar
Department of Neonatology, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Department of Pediatrics, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Am J Perinatol. 2023 Apr;40(5):508-512. doi: 10.1055/s-0041-1729556. Epub 2021 May 3.
The etiology of anemia in premature neonates is multifactorial and may involve anemia of inflammation mediated by hepcidin. Hepcidin expression is suppressed by vitamin D. We aimed to investigate the interrelationship between hepcidin, anemia, and vitamin D status in preterm infants.
Preterm infants aged 1 to 5 weeks were prospectively recruited at the neonatal intensive care unit of the Dana Dwek Children Hospital. Blood counts and serum levels of hepcidin, ferritin, iron, 25-hydroxyvitamin D [25(OH)D] and C-reactive protein (CRP) were measured and compared between anemic and nonanemic preterm infants.
Forty-seven preterm infants (mean ± standard deviation gestational age at birth 32.8 ± 1.1 weeks, 66% males) were recruited. In total, 36% of the preterm infants were vitamin D deficient [25(OH)D < 20 ng/mL] and 15% were anemic. Hepcidin levels were significantly higher in anemic premature infants than in the nonanemic group (55.3 ± 23.9 ng/mL vs. 30.1 ± 16.3 ng/mL, respectively, < 0.05). No differences were found in iron, ferritin, 25(OH)D, and CRP levels between anemic and nonanemic premature newborn infants. A positive correlation was found between hepcidin and ferritin ( = 0.247, = 0.02) and a negative correlation was found between 25(OH)D and CRP ( = 0.1, = 0.04). No significant correlations were found between 25(OH)D and hepcidin, iron, ferritin, or CRP.
Anemia of prematurity was associated with high hepcidin serum levels. The exact mechanisms leading to anemia and the role of vitamin D warrant further investigation.
· Hepcidin levels were significantly higher in anemic premature infants.. · A positive correlation was found between hepcidin and ferritin.. · Negative correlation was found between 25(OH)D and CRP..
早产儿贫血的病因是多因素的，可能涉及铁调素介导的炎症性贫血。维生素D可抑制铁调素的表达。我们旨在研究早产儿中铁调素、贫血和维生素D状态之间的相互关系。
在达纳·德维克儿童医院新生儿重症监护病房前瞻性招募1至5周龄的早产儿。测量并比较贫血和非贫血早产儿的血细胞计数以及血清铁调素、铁蛋白、铁、25-羟基维生素D[25(OH)D]和C反应蛋白(CRP)水平。
共招募了47名早产儿（出生时平均胎龄±标准差为32.8±1.1周，66%为男性）。总体而言，36%的早产儿维生素D缺乏[25(OH)D＜20 ng/mL]，15%的早产儿贫血。贫血早产儿的铁调素水平显著高于非贫血组（分别为55.3±23.9 ng/mL和30.1±16.3 ng/mL，＜0.05）。贫血和非贫血早产新生儿之间的铁、铁蛋白、25(OH)D和CRP水平未发现差异。铁调素与铁蛋白之间呈正相关（=0.247，=0.02），25(OH)D与CRP之间呈负相关（=0.1，=0.04）。25(OH)D与铁调素、铁、铁蛋白或CRP之间未发现显著相关性。
早产贫血与血清铁调素水平升高有关。导致贫血的确切机制以及维生素D的作用值得进一步研究。
·贫血早产儿的铁调素水平显著更高。·铁调素与铁蛋白之间呈正相关。·25(OH)D与CRP之间呈负相关。
