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微流控纺丝制备用于组织工程和药物输送的微纤维的最新进展。

Recent Advances in Microfluidically Spun Microfibers for Tissue Engineering and Drug Delivery Applications.

机构信息

Department of Mechanical Engineering, Iowa State University, Ames, Iowa 50011, USA; email:

Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011, USA.

出版信息

Annu Rev Anal Chem (Palo Alto Calif). 2021 Jul 27;14(1):185-205. doi: 10.1146/annurev-anchem-090420-101138.

Abstract

In recent years, the unique and tunable properties of microfluidically spun microfibers have led to tremendous advancements for the field of biomedical engineering, which have been applied to areas such as tissue engineering, wound dressing, and drug delivery, as well as cell encapsulation and cell seeding. In this article, we analyze the most recent advances in microfluidics and microfluidically spun microfibers, with an emphasis on biomedical applications. We explore in detail these new and innovative experiments, how microfibers are made, the experimental purpose of making microfibers, and the future work that can be done as a result of these new types of microfibers. We also focus on the applications of various materials used to fabricate microfibers, as well as their many promises and limitations.

摘要

近年来,微流控纺丝微纤维的独特和可调谐特性为生物医学工程领域带来了巨大的进步,这些进步已应用于组织工程、伤口敷料和药物输送以及细胞封装和细胞播种等领域。本文分析了微流控技术和微流控纺丝微纤维的最新进展,重点介绍了其在生物医学方面的应用。我们详细探讨了这些新的创新性实验、微纤维的制造方法、制造微纤维的实验目的以及由于这些新型微纤维而可以开展的未来工作。我们还关注用于制造微纤维的各种材料的应用及其诸多的承诺和局限性。

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