Kochina E N, Nasonova S V, Radenska-Lopovok S, Popova I V, Proskurneva E P
Ter Arkh. 1988;60(4):40-6.
The clinicofunctional and morphological status of the stomach, biliferous system, pancreas, large and small intestine was studied in 83 patients with Sjogren's syndrome and disease (SS and SD). Chronic gastritis with secretory insufficiency was shown to develop in SD. Morphological changes of the gastric mucosa were represented by chronic gastritis with glandular involvement and chronic atrophic gastritis of immune genesis. Pathology of the extrahepatic system of bilification was detected in 87% of patients. The most common pathologies diagnosed in these patients were chronic cholecystitis (51%) and biliary dyskinesia (25%). Changes of the chemical composition of the bile (arise of its lythogenic properties) were observed. Various disorders of pancreatic function were detected in 85% of SS and SD patients. X-ray and endoscopic investigations revealed duodenal, intestinal and colon hypokinesia, less frequently signs of enteritis and colitis in one-third of the patients. The irritable colon syndrome was found in 40%. On the whole, involvement of different parts of the intestine was observed in 92%. Morphological changes in the duodenal and sigmoid colon mucosa were typical of chronic diffuse duodenitis and sigmoiditis in a subacute SD course, and chronic atrophic duodenitis and sigmoiditis in a chronic SD and SS course.
对83例干燥综合征患者（SS）和干燥综合征相关疾病患者（SD）的胃、胆系、胰腺以及大肠和小肠的临床功能和形态学状况进行了研究。结果显示，SD患者会出现伴有分泌功能不全的慢性胃炎。胃黏膜的形态学变化表现为伴有腺体受累的慢性胃炎以及免疫源性慢性萎缩性胃炎。87%的患者检测出肝外胆汁生成系统的病变。这些患者中最常见的病变为慢性胆囊炎（51%）和胆汁运动障碍（25%）。观察到胆汁化学成分的变化（其致石特性出现）。85%的SS和SD患者检测出各种胰腺功能障碍。X线和内镜检查显示十二指肠、肠道和结肠运动功能减退，三分之一的患者较少出现肠炎和结肠炎的体征。40%的患者发现有肠易激综合征。总体而言，92%的患者观察到肠道不同部位受累。十二指肠和乙状结肠黏膜的形态学变化在亚急性SD病程中表现为慢性弥漫性十二指肠炎症和乙状结肠炎症，在慢性SD和SS病程中表现为慢性萎缩性十二指肠炎症和乙状结肠炎症。
