布氏锥虫、罗德西亚锥虫和冈比亚锥虫对人血浆的抗性：III. 两株抗血浆菌株的克隆

The resistance to human plasma of Trypanosoma brucei, T. rhodesiense and T. gambiense: III. Clones of two plasma-resistant strains.

作者信息

Hawking F

出版信息

Trans R Soc Trop Med Hyg. 1977;71(5):427-30. doi: 10.1016/0035-9203(77)90045-1.

Abstract

Tests for resistance to human plasma were made on six clones of a stabilate of Trypanosoma rhodesiense (LUMP 10) which was calculated to contain about 3,000 resistant trypanosomes per million. Two of the clones were not resistant and four were only subresistant. Tests were also made on 12 lines (clones) of a stabilate of polymorphic trypanosomes isolated from tsetse flies. One of them, ETAT 10, had infected a laboratory worker and was found to be fully resistant to human plasma; the other lines showed only low or moderate resistance. Resistance of a strain to human plasma often depends upon a small minority of resistant trypanosomes. Strains of polymorphic trypanosomes may be classified as fully resistant, moderately resistant, subresistant, or sensitive to human plasma, if they contain respectively, all, some (e.g. one per hundred), very few (e.g. one per million) or no individuals which are resistant.

摘要

对罗得西亚锥虫（LUMP 10）保种培养物的六个克隆进行了抗人血浆试验，该保种培养物估计每百万含有约3000个抗性锥虫。其中两个克隆无抗性，四个仅为亚抗性。还对从采采蝇分离的多态性锥虫保种培养物的12个品系（克隆）进行了试验。其中一个品系ETAT 10感染了一名实验室工作人员，发现它对人血浆完全有抗性；其他品系仅表现出低抗性或中等抗性。一个菌株对人血浆的抗性通常取决于一小部分抗性锥虫。如果多态性锥虫菌株分别含有全部、一些（例如每一百个中有一个）、极少数（例如每百万个中有一个）或没有抗性个体，则可将其分类为对人血浆完全有抗性、中等有抗性、亚抗性或敏感。