Horton M A, Fowler P, Simpson A, Onions D
Department of Haematology, St Bartholomew's Hospital, London, Great Britain.
Vet Immunol Immunopathol. 1988 Apr;18(3):213-7. doi: 10.1016/0165-2427(88)90065-7.
Immunological techniques have been used to study the expression of a series of cell surface antigens in cat haemopoietic tissues. Forty-two monoclonal antibodies raised against well-defined antigens of human origin were tested by indirect immunofluorescence on feline blood, bone marrow, spleen and thymus. Myeloid cells from all tissues reacted with antibodies to CD9, CD10 and CD18 antigens. No antibodies specific for T or B lymphocytes were found to react with cat lymphoid cells. Osteoclasts, isolated from juvenile bone marrow, were found to express the 23C6 human osteoclast-specific antigen. The potential use of such antibodies in experimental and diagnostic veterinary haematology are discussed.
免疫技术已被用于研究猫造血组织中一系列细胞表面抗原的表达。通过间接免疫荧光法，在猫的血液、骨髓、脾脏和胸腺上测试了针对明确的人类来源抗原产生的42种单克隆抗体。所有组织中的髓样细胞都与针对CD9、CD10和CD18抗原的抗体发生反应。未发现对T或B淋巴细胞特异的抗体与猫淋巴细胞发生反应。从幼年骨髓中分离出的破骨细胞被发现表达23C6人类破骨细胞特异性抗原。讨论了此类抗体在实验性和诊断性兽医血液学中的潜在用途。
