Qin Xiao-Yan, Wang Jia-Yin, Geng Fang-Zhou, Hao Wen-Juan, Tu Shu-Jiang, Jiang Bo
School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou, 221116, P. R. China.
Chem Commun (Camb). 2021 Jun 1;57(44):5394-5397. doi: 10.1039/d1cc01422f.
New tunable catalytic [2+2] cycloaddition/silane-mediated conjugate transfer reductions of yne-allenones have been developed, by which substituent-diverse cyclobutarenes with generally good yields were selectively synthesized by adjusting Fe-H and Cu-H catalytic systems. Use of the Fe-H system triggers 1,6-conjugate reduction to dihydrocyclobuta[a]naphthalen-4-ols whereas the Cu-H complex enables 1,4-conjugate reduction to cyclobuta[a]naphthalen-4(2H)-ones.
已开发出新型可调谐催化的[2+2]环加成/硅烷介导的烯炔酮共轭转移还原反应，通过该反应，通过调节铁-氢和铜-氢催化体系，可选择性地合成取代基多样且产率普遍良好的环丁芳烃。使用铁-氢体系引发1,6-共轭还原生成二氢环丁[a]萘-4-醇，而铜-氢配合物则实现1,4-共轭还原生成环丁[a]萘-4(2H)-酮。
