Izadi Mahin, Khalili Mohammad Ali, Salehi-Abargouei Amin, Rezvani Mohammad Ebrahim, Aflatoonian Behrouz
Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Reproductive Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Andrologia. 2021 Jul;53(6):e14022. doi: 10.1111/and.14022. Epub 2021 May 4.
Zona pellucida (ZP)-bound spermatozoa have normal morphology and motility and can enhance the ICSI outcomes. Selection of zona pellucida-bound spermatozoa is recently considered to find functional spermatozoa for ICSI. This study reviewed the efficacy of ZP-bound sperm selection on the ICSI outcomes includes fertilisation rate, embryo quality, embryo transfer rate and clinical pregnancy rate. The databases searched include PubMed, Scopus and Cochrane databases up to January 2019. All research reports with full text and in English language that addressing the relation between ZP-sperm selection and ICSI outcomes were included. Fifty studies were suitable after screening of the 845 identified articles. After exclusions, five of these studies were included. Meta-analytic pooling of data indicated no association between the ICSI outcomes and ZP-bound sperm selection except a marginal effect on implantation rate. Eliminating one study indicated that ZP-bound sperm selection technique improves embryo quality, implantation rate and clinical pregnancy rate. This study revealed that ZP-bound sperm selection produces only a slight improvement in implantation rate. However, further studies with a large number of couples must be done to clarify the potential beneficial effect of ZP-bound spermatozoa on ICSI outcomes.
与透明带（ZP）结合的精子具有正常形态和活力，并且可以提高卵胞浆内单精子注射（ICSI）的成功率。近来，选择与透明带结合的精子被认为是寻找用于ICSI的功能性精子的方法。本研究回顾了选择与透明带结合的精子对ICSI成功率的影响，包括受精率、胚胎质量、胚胎移植率和临床妊娠率。检索的数据库包括截至2019年1月的PubMed、Scopus和Cochrane数据库。纳入所有涉及ZP-精子选择与ICSI成功率之间关系的全文英文研究报告。在对845篇已识别文章进行筛选后，有50项研究符合要求。排除后，纳入其中5项研究。数据的荟萃分析表明，ICSI成功率与选择与透明带结合的精子之间无关联，但对着床率有轻微影响。排除一项研究后表明，选择与透明带结合的精子技术可提高胚胎质量、着床率和临床妊娠率。本研究表明，选择与透明带结合的精子仅能使着床率略有提高。然而，必须对大量夫妇进行进一步研究，以阐明选择与透明带结合的精子对ICSI成功率的潜在有益影响。
