离体犬动脉对组胺反应的异质性。

Heterogeneity in the response to histamine of isolated dog arteries.

作者信息

Sotníková R, Gibala P, Drímal J

机构信息

Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.

出版信息

Agents Actions. 1988 Apr;23(3-4):270-2. doi: 10.1007/BF02142561.

DOI:10.1007/BF02142561

PMID:3394574

Abstract

Arterial rings were used to evaluate the differences in the effect of histamine (HIS) on canine dorsal pedal (DPA) and coronary arteries. Moreover, the responses of intact coronary arteries (IA) to HIS were compared with those of arteries isolated from sham operated dogs (SA) and from dogs in the late postinfarction period (PA). DPA responded to HIS added cumulatively with contraction which was potentiated by cimetidine (CIM) and reversed by mepyramine (MEP). IA responded with relaxation potentiated by MEP and reversed by CIM. Under resting conditions, coronary arteries responded to a single concentration of HIS with contraction or relaxation (in IA, SA). In PA, only contractions were seen. Responses of PA were significantly higher than those of IA and SA. It appears that in PA the ratio of H1- and H2-receptors is changed.

摘要

采用动脉环来评估组胺（HIS）对犬背侧足背动脉（DPA）和冠状动脉作用的差异。此外，还比较了完整冠状动脉（IA）对HIS的反应与假手术犬（SA）和心肌梗死后晚期犬（PA）分离出的动脉的反应。DPA对累积添加的HIS产生收缩反应，西咪替丁（CIM）可增强该反应，而美吡拉敏（MEP）可逆转该反应。IA对HIS产生舒张反应，MEP可增强该反应，CIM可逆转该反应。在静息条件下，冠状动脉对单一浓度的HIS产生收缩或舒张反应（IA、SA中为舒张）。在PA中，仅见收缩反应。PA的反应明显高于IA和SA。似乎在PA中，H1和H2受体的比例发生了变化。