Univ Paris Est Creteil (UPEC), AP-HP, Hôpitaux Universitaires « H. Mondor », DMU IMPACT, INSERM, IMRB, translational Neuropsychiatry, Fondation FondaMental F-94010 Creteil, France.
Univ Paris Est Creteil (UPEC), AP-HP, Hôpitaux Universitaires « H. Mondor », DMU IMPACT, INSERM, IMRB, translational Neuropsychiatry, Fondation FondaMental F-94010 Creteil, France.
Psychiatry Res. 2021 Jul;301:113941. doi: 10.1016/j.psychres.2021.113941. Epub 2021 Apr 18.
Both shorter telomeres and schizophrenia have been associated with a decrease in life expectancy. Furthermore, several studies found a shorter telomere length (TL) in schizophrenia. Understanding whether or not telomere shortening is directly related to pathophysiology of schizophrenia or is a consequence of a cumulative exposure to chronic stress is of major importance. Comparing the TL of subjects at the very beginning of the disease (FEP) and control subjects could help to decide between these two hypotheses. The aim of the present study was to compare TL between FEP subjects (N=91) and controls (N=137). After accounting for multiple potential confounders, no significant association was observed between FEP and TL. Our result is consistent with the hypothesis that psycho-social stress / adversities and stressful situations in people with schizophrenia affect TL rather than that telomere erosion contributes to the development of this disorder.
端粒较短与精神分裂症都与预期寿命缩短有关。此外，多项研究发现精神分裂症患者的端粒长度较短。了解端粒缩短是否与精神分裂症的病理生理学直接相关，还是慢性压力累积暴露的结果，这一点非常重要。比较疾病早期（FEP）患者和对照组的端粒长度有助于在这两种假设之间做出选择。本研究的目的是比较 FEP 患者（N=91）和对照组（N=137）之间的端粒长度。在考虑了多个潜在的混杂因素后，FEP 与 TL 之间没有观察到显著关联。我们的结果与以下假设一致，即精神分裂症患者的心理社会压力/逆境和压力情况会影响 TL，而不是端粒侵蚀会导致这种疾病的发展。
