Kałużewski Tadeusz, Przybylski Grzegorz K, Bednarek Michał, Glazar Sławomir, Grabiec Magdalena, Jędrzejczyk Adam, Kępczyński Łukasz, Kubiak Izabela, Kucharska Dorota, Morel Agnieszka, Owczarek Magdalena, Rożniecki Marek, Sałamunia Jordan, Szewczyk Dominika, Szwalski Jarosław, Kałużewski Bogdan
Laboratory of Medical Genetics of the "Genos" Partnership-R&D Division, 91-033 Lodz, Poland.
Department of Genetics, Polish Mother's Memorial Hospital Research Institute, 93-338 Lodz, Poland.
J Pers Med. 2021 Apr 30;11(5):362. doi: 10.3390/jpm11050362.
Bladder cancer is one of the most common cancers in global statistics. One of the issues associated with this disease is the high incidence of cases with delayed diagnosis and what factors correlate with worse treatment outcomes. A possible reason for this may be the rather limited availability of non-invasive diagnostic tools. This short communication presents a case of a 68 year old male patient after an ineffective therapy, carried on for several years with symptoms commonly associated with prostate overgrowth that masked a carcinoma in situ of the urinary bladder. Implementation of several diagnostic techniques, including urine sediment cytology, immunocytochemistry, the fluorescence in situ hybridisation technique, the Bladder EpiCheck test and whole-genome sequencing, enabled the establishment of a correct diagnosis, implementation of appropriate treatment and provision of patient-friendly monitoring. The described case emphasises the usefulness of cell-based and liquid-based urine tests in bladder cancer diagnostic procedures.
在全球统计数据中，膀胱癌是最常见的癌症之一。与这种疾病相关的问题之一是延迟诊断病例的高发生率以及哪些因素与较差的治疗结果相关。造成这种情况的一个可能原因是非侵入性诊断工具的可用性相当有限。本简短通讯介绍了一例68岁男性患者的病例，该患者在进行了数年无效治疗后，其症状通常与前列腺增生相关，掩盖了膀胱原位癌。实施多种诊断技术，包括尿沉渣细胞学检查、免疫细胞化学、荧光原位杂交技术、膀胱EpiCheck检测和全基因组测序，使得能够建立正确的诊断、实施适当的治疗并提供方便患者的监测。所描述的病例强调了基于细胞和基于液体的尿液检测在膀胱癌诊断程序中的有用性。
