染色质重塑在大脑发育中的演变。

Department of Cell and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

Ottawa Health Research Institute (OHRI), Ottawa, ON K1H 8L6, Canada.

Int J Mol Sci. 2021 Apr 30;22(9):4768. doi: 10.3390/ijms22094768.

During brain development, the genome must be repeatedly reconfigured in order to facilitate neuronal and glial differentiation. A host of chromatin remodeling complexes facilitates this process. At the genetic level, the non-redundancy of these complexes suggests that neurodevelopment may require a lexicon of remodelers with different specificities and activities. Here, we focus on the nucleosome remodeling and deacetylase (NuRD) complex. We review NuRD biochemistry, genetics, and functions in neural progenitors and neurons.

在大脑发育过程中，基因组必须反复重新配置，以促进神经元和神经胶质细胞的分化。许多染色质重塑复合物有助于这一过程。在遗传水平上，这些复合物的非冗余性表明神经发育可能需要具有不同特异性和活性的重塑剂词典。在这里，我们专注于核小体重塑和去乙酰化酶（NuRD）复合物。我们回顾了 NuRD 的生化、遗传学和在神经祖细胞和神经元中的功能。