Department of Surgical Sciences, Uppsala University, 751 85 Uppsala, Sweden.
Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
Nutrients. 2021 Apr 29;13(5):1504. doi: 10.3390/nu13051504.
Fibroblast growth factor 21 (FGF21) is a human metabolic hormone whose effects include modification of macronutrient preference and energy homeostasis. In animal models, FGF21 has been shown to have beneficial effects on cardiometabolic outcomes, Alzheimer's disease risk and lifespan. In this study, the single-nucleotide polymorphism rs838133 in the gene region was leveraged to investigate the potential clinical effects of targeting FGF21. The G allele was associated with lower intakes of total sugars and alcohol, and higher intakes of protein and fat as well as favourable with lipid levels, blood pressure traits, waist-to-hip ratio, systemic inflammation, cardiovascular outcomes, Alzheimer's disease risk and lifespan. These findings may be used to anticipate the effects of pharmacologically increasing FGF21 signalling.
成纤维细胞生长因子 21（FGF21）是一种人类代谢激素，其作用包括改变宏量营养素的偏好和能量平衡。在动物模型中，FGF21 已被证明对心脏代谢结局、阿尔茨海默病风险和寿命有有益的影响。在这项研究中，利用基因区域中的单核苷酸多态性 rs838133 来研究靶向 FGF21 的潜在临床效果。G 等位基因与总糖和酒精的摄入量较低，而蛋白质和脂肪的摄入量较高，以及血脂水平、血压特征、腰臀比、全身炎症、心血管结局、阿尔茨海默病风险和寿命较好相关。这些发现可用于预测药理增加 FGF21 信号的效果。
