Kissova Viera, Zelko Aurel, Rosenberger Jaroslav, Geckova Andrea Madarasova
Clinic of Internal Medicine I, Comenius University, Bratislava, Slovakia.
Department of Health Psychology and Research Methodology, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, Slovakia.
Endocrinol Diabetes Nutr (Engl Ed). 2021 May 1. doi: 10.1016/j.endinu.2021.02.002.
The purpose of this study is to identify the role of diabetes mellitus in the effectiveness of intradialytic exercise intervention among haemodialysis patients.
In this multicentre study 90 dialysed patients were allocated to the experimental (EXG, n=57) or control group (CNG, n=33). In EXG, we included 20 diabetic and 37 non-diabetic patients. In CNG, we enrolled 8 diabetic and 25 non-diabetic patients. EXG underwent a 12-week supervised, progressive, intradialytic resistance training programme, while CNG stayed inactive during dialysis. Baseline, post-interventional and post-follow-up assessments of maximal force during hip extension (HE), hip flexion (HF) and knee extension (KE) contractions were completed in both groups of patients.
HE increased in diabetic and non-diabetic EXG patients (diabetic EXG, change: +14.5N; 95% CI=-5.5 to +34.5; non-diabetic EXG, +18.6N; 95% CI=+3.4 to +33.8) and diabetic CNG patients (change: +17.9N; 95% CI=-9.2 to +44.9). Only non-diabetic CNG patients experienced a decrease in HE (change: -22.8N; 95% CI=-36.9 to -8.7, P<.05).
Resistance training improved muscle function among dialysis patients regardless of the presence of diabetes mellitus. We found that non-diabetic patients lose their muscle function extensively during inactivity, while diabetic patients retain their muscle function.
本研究旨在确定糖尿病在血液透析患者透析期间运动干预效果中的作用。
在这项多中心研究中，90名透析患者被分配到实验组（EXG，n = 57）或对照组（CNG，n = 33）。在EXG组中，我们纳入了20名糖尿病患者和37名非糖尿病患者。在CNG组中，我们招募了8名糖尿病患者和25名非糖尿病患者。EXG组接受了为期12周的有监督的、渐进性的透析期间阻力训练计划，而CNG组在透析期间保持不活动状态。两组患者均完成了髋伸展（HE）、髋屈曲（HF）和膝伸展（KE）收缩期间最大力量的基线、干预后和随访后评估。
糖尿病和非糖尿病EXG组患者的HE均增加（糖尿病EXG组，变化：+14.5N；95%CI = -5.5至+34.5；非糖尿病EXG组，+18.6N；95%CI = +3.4至+33.8），糖尿病CNG组患者的HE也增加（变化：+17.9N；95%CI = -9.2至+44.9）。只有非糖尿病CNG组患者的HE有所下降（变化：-22.8N；95%CI = -36.9至-8.7，P <.05）。
无论是否患有糖尿病，阻力训练都能改善透析患者的肌肉功能。我们发现，非糖尿病患者在不活动期间肌肉功能会大幅丧失，而糖尿病患者则能保持其肌肉功能。
