新型精神活性物质使用的急性神经学后果：英国一家大型医院的回顾性研究
Acute neurological consequences of novel psychoactive substance use: a retrospective review in a large UK hospital.
作者信息
Tanti Matthew, Cosgrove Jeremy, Kelleher Charles, Jones Rebekah, Maguire Melissa
机构信息
Leeds Teaching Hospitals NHS Trust, Leeds, UK
Leeds Teaching Hospitals NHS Trust, Leeds, UK.
出版信息
Clin Med (Lond). 2021 May;21(3):189-194. doi: 10.7861/clinmed.2020-0706. Epub 2021 May 4.
BACKGROUND
Novel psychoactive substances (NPS) are a growing public health concern. We aimed to identify the acute neurological consequences of NPS.
METHOD
We performed a retrospective case-note review of patients who presented to the emergency department after taking NPS.
RESULTS
We identified 237 admissions from 190 patients, mostly young men. There were high rates of psychiatric comorbidity (43%), unemployment (39%), homelessness (24%) and incarceration (17%). Most reported use of synthetic cannabinoids (SC; 91%). Some took synthetic cathinones (SCath; 7%) or nitrous oxide (NOS; 2%). SC caused impaired consciousness (61%) and seizures (16%). SCath users presented with psychiatric disturbance or seizures (55%). Most patients were managed conservatively (67%) and a small proportion (14%) were referred to drug or psychology services.
CONCLUSIONS
NPS users represent a vulnerable group in society. Certain clinical features may suggest the type of NPS used. Most patients require supportive management and onward referral to drug addiction services is recommended.
背景
新型精神活性物质（NPS）日益引起公众对健康的关注。我们旨在确定新型精神活性物质的急性神经学后果。
方法
我们对服用新型精神活性物质后到急诊科就诊的患者进行了回顾性病例记录审查。
结果
我们确定了190名患者的237次入院情况，其中大多数是年轻男性。精神疾病合并症（43%）、失业（39%）、无家可归（24%）和监禁（17%）的发生率很高。大多数人报告使用合成大麻素（SC；91%）。一些人使用合成卡西酮（SCath；7%）或一氧化二氮（NOS；2%）。合成大麻素导致意识障碍（61%）和癫痫发作（16%）。使用合成卡西酮的患者出现精神障碍或癫痫发作（55%）。大多数患者接受保守治疗（67%），一小部分（14%）被转介到药物或心理服务机构。
结论
新型精神活性物质使用者是社会中的弱势群体。某些临床特征可能提示所使用的新型精神活性物质类型。大多数患者需要支持性治疗，建议将其转诊至药物成瘾服务机构。
Zotero 插件