缺氧诱导型 CAR 表达：解决靶内/肿瘤外脱靶问题的答案？
Hypoxia-inducible CAR expression: An answer to the on-target/off-tumor dilemma?
机构信息
Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
出版信息
Cell Rep Med. 2021 Apr 20;2(4):100244. doi: 10.1016/j.xcrm.2021.100244.
Abstract
On-target/off-tumor toxicity is one of the major concerns regarding CAR T-cell therapy. Kosti et al. demonstrate that this form of toxicity can be prevented by designing a CAR whose expression is controlled by oxygen levels in the tumor environment.
摘要
针对肿瘤/脱靶毒性是嵌合抗原受体 T 细胞（CAR T 细胞）疗法的主要关注点之一。Kosti 等人证明，通过设计一种由肿瘤微环境中的氧水平控制表达的 CAR，可以预防这种形式的毒性。
Zotero 插件