A new method to calculate intra-patient variability in tacrolimus concentrations.
作者信息
van Gelder Teun
机构信息
Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.
出版信息
Br J Clin Pharmacol. 2022 Jun;88(6):2581-2582. doi: 10.1111/bcp.14865. Epub 2021 May 5.
Abstract
摘要
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A new method to calculate intra-patient variability in tacrolimus concentrations.一种计算他克莫司血药浓度患者内变异性的新方法。
Br J Clin Pharmacol. 2022 Jun;88(6):2581-2582. doi: 10.1111/bcp.14865. Epub 2021 May 5.
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Variability in tacrolimus blood levels increases the risk of late rejection and graft loss after solid organ transplantation in older children.在大龄儿童实体器官移植后，他克莫司血药浓度的变异性会增加晚期排斥反应和移植物丢失的风险。
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Association of graft survival with tacrolimus exposure and late intra-patient tacrolimus variability in pediatric and young adult renal transplant recipients-an international CTS registry analysis.儿童及青年肾移植受者中移植物存活与他克莫司暴露及患者体内他克莫司后期变异性的关联——一项国际CTS注册研究分析
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Intra-patient variability in tacrolimus trough concentrations and renal function decline in pediatric renal transplant recipients.儿童肾移植受者中他克莫司谷浓度的患者内变异性与肾功能下降
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Tacrolimus intra-patient variability is not associated with chronic active antibody mediated rejection.患者内他克莫司变异性与慢性活跃抗体介导的排斥反应无关。
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Intra-graft injection of tacrolimus promotes survival of vascularized composite allotransplantation.移植体内注射他克莫司可促进血管化复合组织异体移植的存活。
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本文引用的文献
1
Tacrolimus variability score outperforms coefficient of variation in predicting clinical outcomes of living kidney transplantation.他克莫司变异系数评分优于变异系数，可预测活体肾移植的临床结局。
Br J Clin Pharmacol. 2022 Jan;88(1):75-83. doi: 10.1111/bcp.14876. Epub 2021 May 12.
2
Etiologies and Outcomes Associated With Tacrolimus Levels Out of a Typical Range That Lead to High Variability in Kidney Transplant Recipients.导致肾移植受者体内他克莫司水平出现高度变异性的典型范围外水平及其相关病因和结果。
Ther Drug Monit. 2021 Jun 1;43(3):401-407. doi: 10.1097/FTD.0000000000000863.
3
Intrapatient Variability of Tacrolimus Exposure in Solid Organ Transplantation: A Novel Marker for Clinical Outcome.实体器官移植中环孢素暴露的患者内变异性：临床转归的新标志物。
Clin Pharmacol Ther. 2020 Feb;107(2):347-358. doi: 10.1002/cpt.1618. Epub 2019 Sep 23.
4
High tacrolimus intra-patient variability is associated with graft rejection, and donor-specific antibodies occurrence after liver transplantation.高他克莫司患者内变异与移植排斥反应和肝移植后供体特异性抗体的发生有关。
World J Gastroenterol. 2018 Apr 28;24(16):1795-1802. doi: 10.3748/wjg.v24.i16.1795.
5
Mean HbA, HbA variability, and mortality in people with diabetes aged 70 years and older: a retrospective cohort study.70 岁及以上糖尿病患者的平均 HbA、HbA 变异性和死亡率：一项回顾性队列研究。
Lancet Diabetes Endocrinol. 2018 Jun;6(6):476-486. doi: 10.1016/S2213-8587(18)30048-2. Epub 2018 Apr 16.
6
Practical Recommendations for Long-term Management of Modifiable Risks in Kidney and Liver Transplant Recipients: A Guidance Report and Clinical Checklist by the Consensus on Managing Modifiable Risk in Transplantation (COMMIT) Group.移植术后可改变风险的长期管理实用建议：移植术后可改变风险共识 (COMMIT) 专家组的指导报告和临床检查表。
Transplantation. 2017 Apr;101(4S Suppl 2):S1-S56. doi: 10.1097/TP.0000000000001651.
7
A high intrapatient variability in tacrolimus exposure is associated with poor long-term outcome of kidney transplantation.他克莫司血药浓度在患者体内的高度变异性与肾移植的长期不良预后相关。
Transpl Int. 2016 Nov;29(11):1158-1167. doi: 10.1111/tri.12798. Epub 2016 Jun 28.
8
High Intrapatient Variability of Tacrolimus Concentrations Predicts Accelerated Progression of Chronic Histologic Lesions in Renal Recipients.患者内他克莫司浓度变异性高可预测肾移植受者慢性组织学病变的加速进展。
Am J Transplant. 2016 Oct;16(10):2954-2963. doi: 10.1111/ajt.13803. Epub 2016 Apr 21.
9
Lower variability in 24-hour exposure during once-daily compared to twice-daily tacrolimus formulation in kidney transplantation.与每日两次的他克莫司制剂相比，每日一次的他克莫司制剂在肾移植中 24 小时暴露的变异性更低。
Transplantation. 2014 Apr 15;97(7):775-80. doi: 10.1097/01.TP.0000437561.31212.0e.
10
Time-dependent variability in tacrolimus trough blood levels is a risk factor for late kidney transplant failure.他克莫司谷浓度的时间依赖性变化是导致晚期肾移植失败的一个危险因素。
Kidney Int. 2014 Jun;85(6):1404-11. doi: 10.1038/ki.2013.465. Epub 2013 Dec 11.
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