Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
J Mol Recognit. 2021 Oct;34(10):e2900. doi: 10.1002/jmr.2900. Epub 2021 May 4.
In this study, the rGO-PEI-AgNPs sensor was designed as a new effective platform to sensitive monitoring of deltamethrin in human plasma samples. For this purpose, reduced graphene oxide (rGO)-supported polyethylenimine (PEI) was used as a suitable substrate for dispersion of silver nanoparticles (AgNPs) as amplification and catalytic element. Therefore, a novel interface (rGO-PEI-AgNPs) was prepared by the fully electrochemical method on the surface of glassy carbon electrodes. The engineered nano-sensor showed a wide dynamic range of 10 nM to 1 mM and low limit of quantification (LLOQ) as 10 nM in human plasma sample, which revealed excellent analytical performance for the recognition of deltamethrin with high sensitivity and reproducibility through differential pulse voltammetry and square wave voltammetry techniques. The results confirm that rGO-PEI-AgNPs as a novel biocompatible interface can provide appropriate, reliable, affordable, rapid, and user-friendly diagnostic tools in the detection of deltamethrin in human real samples.
在这项研究中，设计了 rGO-PEI-AgNPs 传感器作为一种新的有效平台，用于灵敏监测人血浆样品中的溴氰菊酯。为此，还原氧化石墨烯（rGO）负载的聚乙烯亚胺（PEI）被用作分散银纳米粒子（AgNPs）的合适基质，作为放大和催化元件。因此，通过全电化学方法在玻碳电极表面制备了一种新型界面（rGO-PEI-AgNPs）。所设计的纳米传感器在人血浆样品中表现出 10 nM 至 1 mM 的宽动态范围和低定量下限（LLOQ）为 10 nM，通过差分脉冲伏安法和方波伏安法技术对溴氰菊酯具有高灵敏度和重现性的识别，显示出优异的分析性能。结果证实，rGO-PEI-AgNPs 作为一种新型的生物相容性界面，可以为检测人真实样品中的溴氰菊酯提供合适、可靠、经济、快速和用户友好的诊断工具。
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