流式细胞术 CLL 评分的一致性。

Concordance between flow cytometry CLL scores.

机构信息

Hematology Laboratory, ICO-Hospital Germans Trias i Pujol. Functional Cytomics- IJC, LUMN, Universitat Autònoma de Barcelona, Badalona, Spain.

出版信息

Int J Lab Hematol. 2021 Aug;43(4):743-751. doi: 10.1111/ijlh.13567. Epub 2021 May 4.

DOI:10.1111/ijlh.13567

PMID:33949096

Abstract

INTRODUCTION

Multiple flow cytometry scores/diagnostic systems for the classification of leukemic lymphoproliferative disorders (LPD) have been published but few have been compared between them.

PATIENTS AND METHODS

We classified a cohort of leukemic LPD based on eleven published flow cytometry scores/diagnostic systems and compared their classification as chronic lymphocytic leukemia (CLL) or non-CLL LPD.

RESULTS

329 patients were included. Patients classified as CLL ranged from 46% to 73%, depending on the score/diagnostic system used. All eleven scores/diagnostic systems agreed in 184/324 (57%) of patients while in 58/324 (18%) at least two scores/diagnostic systems classified the patient differently (from the majority). Fleiss kappa was 0.74, but pairwise agreement was variable (Cohen's kappa: 0.48 to 0.87).

CONCLUSION

This study found a suboptimal agreement between published flow cytometry scores/diagnostic systems for the classification of LPD.

摘要

简介

已有多个流式细胞术评分/诊断系统用于白血病性淋巴增殖性疾病（LPD）的分类，但它们之间很少进行比较。

患者与方法

我们根据十一种已发表的流式细胞术评分/诊断系统对白血病性 LPD 进行分类，并比较了它们作为慢性淋巴细胞白血病（CLL）或非 CLL LPD 的分类。

结果

共纳入 329 例患者。根据评分/诊断系统的不同，CLL 患者的比例范围为 46%至 73%。11 种评分/诊断系统在 324 例患者中的 184 例（57%）中一致，而在 324 例患者中的 58 例（18%）中至少两种评分/诊断系统将患者分类为不同的疾病（与多数情况不一致）。Fleiss kappa 值为 0.74，但两两之间的一致性存在差异（Cohen's kappa：0.48 至 0.87）。