Clark E S, Thompson S A, Becht J L, Moore J N
Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
Am J Vet Res. 1988 May;49(5):720-3.
Mechanical activity of the cecal body, lateral cecal arterial blood flow, carotid arterial pressure, and heart rate were measured in 6 conscious healthy horses 30 minutes before and for 120 minutes after IV administration of xylazine at dosages of 1.1 mg/kg of body weight, 0.55 mg/kg, and 0.275 mg/kg. Xylazine at a dosage of 1.1 mg/kg reduced the mean motility index (the product of the mean amplitude of contractions and the total duration of contractile activity divided by the recording time) of the circular and longitudinal muscle layers for the first, second, third, and fourth 30-minute periods after administration of xylazine. Xylazine at a dosage of 0.55 mg/kg reduced the motility index of the circular and longitudinal muscle layers for the first and second 30-minute periods after administration of xylazine. Xylazine at a dosage of 0.275 mg/kg reduced the motility index of the circular and longitudinal muscle layers for the first 30-minute period after administration of xylazine. Mean lateral cecal arterial blood flow was significantly (P less than 0.05) lower than the base-line value at 2 and 4 minutes after administration of all 3 xylazine dosages and at 8 minutes after administration of xylazine dosages of 1.1 mg/kg and 0.55 mg/kg. All dosages of xylazine caused transient hypertension and bradycardia, followed by hypotension.
在6匹清醒健康的马身上，于静脉注射不同剂量（1.1毫克/千克体重、0.55毫克/千克和0.275毫克/千克）赛拉嗪前30分钟及注射后120分钟，测量盲肠体的机械活动、盲肠外侧动脉血流量、颈动脉压和心率。剂量为1.1毫克/千克的赛拉嗪在注射后第一个、第二个、第三个和第四个30分钟时间段内，降低了环行肌层和纵行肌层的平均运动指数（收缩平均幅度与收缩活动总持续时间的乘积除以记录时间）。剂量为0.55毫克/千克的赛拉嗪在注射后第一个和第二个30分钟时间段内，降低了环行肌层和纵行肌层的运动指数。剂量为0.275毫克/千克的赛拉嗪在注射后第一个30分钟时间段内，降低了环行肌层和纵行肌层的运动指数。在注射所有3种剂量赛拉嗪后的2分钟和4分钟，以及注射1.1毫克/千克和0.55毫克/千克赛拉嗪剂量后的8分钟，盲肠外侧平均动脉血流量显著低于基线值（P<0.05）。所有剂量的赛拉嗪均引起短暂性高血压和心动过缓，随后出现低血压。
