Maziarz R T, Tepler I, Antin J H, Keroack M A, Churchill W H, Holmes W, Rappeport J
Brigham and Women's Hospital, Boston, Massachusetts.
Ann Intern Med. 1988 Aug 15;109(4):292-4. doi: 10.7326/0003-4819-109-4-292.
A patient with debilitating hairy cell leukemia and documented Mycobacterium avium intracellulare infection unresponsive to standard antituberculous therapy who was treated with alpha-interferon is described. A rapid clinical response with correction of underlying pancytopenia and eradication of the atypical mycobacteria infection was found. No deleterious effects from alpha-interferon therapy were found. The associated resolution of anergy and the sterilization of bone marrow suggest that the reversal of host cellular immune defects led to the eventual control of this patient's infection.
描述了一名患有难治性毛细胞白血病且有细胞内鸟分枝杆菌感染记录的患者，该患者对标准抗结核治疗无反应，接受了α干扰素治疗。发现患者出现了快速的临床反应，基础全血细胞减少得到纠正，非典型分枝杆菌感染得以根除。未发现α干扰素治疗有有害影响。无反应性的相关缓解和骨髓的灭菌表明，宿主细胞免疫缺陷的逆转导致了该患者感染的最终控制。
