小叶间区 2 型肝细胞：肝脏内稳态的守门员。

Midlobular zone 2 hepatocytes: A gatekeeper of liver homeostasis.

机构信息

Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Division of Diabetes and Metabolism, The Institute for Medical Science Asahi Life Foundation, Tokyo, Japan; Department of Clinical Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Tokyo, Japan; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.

出版信息

Cell Metab. 2021 May 4;33(5):855-856. doi: 10.1016/j.cmet.2021.04.005.

DOI:10.1016/j.cmet.2021.04.005

PMID:33951471

Abstract

The liver consists of different zones that vary in function depending on their lobular localization. It remained unclear which zone serves as a source of repopulating/regenerating hepatocytes; however, experiments by Wei et al. (2021) in 11 CreER knockin murine strains revealed a vital role for zone 2 hepatocytes in liver homeostasis.

摘要

肝脏由不同的区域组成，这些区域的功能因其在肝小叶中的定位而有所不同。目前尚不清楚哪个区域是肝再生细胞的来源；然而，Wei 等人（2021 年）在 11 种 CreER 敲入鼠系中的实验表明，2 区肝细胞在肝脏稳态中起着至关重要的作用。