Institute of Cardiovascular Sciences, University of Birmingham, UK; Department of Vascular Surgery, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, UK.
Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK.
Ann Vasc Surg. 2021 Oct;76:351-356. doi: 10.1016/j.avsg.2021.04.018. Epub 2021 May 2.
Previous studies, mainly from the United States, have reported worse outcomes from lower limb bypass procedures in ethnic minority populations. Limited nationwide data are available from ethnic minority populations from Europe. The aim of this study is to investigate outcomes from lower limb bypass procedures in ethnic minorities from England.
We enquired the "Hospital Episode Statistics" database, using ICD-10 codes to identify all cases of femoral-popliteal bypass operations from English NHS Hospitals from 01/01/2006 to 31/12/2015. Every case was followed up for 2 years for subsequent events. The primary outcomes were mortality and major leg amputation. Patients were broadly categorised according to Black, Asian and White ethnicity. Chi-square test was used to the ethnic groups and odds ratios (OR) were calculated using White ethnic group with the largest numbers of participants as a reference category.
In the examined 10-year period, 20825 femoral-popliteal bypass procedures (250 of Black, 167 of Asian, and 20.408 of White ethnicity) were recorded. Thirty-day and 2-year mortality were 2.8% and 16.8% with no significant ethnic differences. Patients of Black ethnicity had higher risk of limb loss compared to Whites (23.2% vs. 15.6%, OR = 1.63, 95% confidence interval (CI) 1.21-2.19, P < 0.01). There was no significant difference in amputation rates between Asians and Whites (16.2% vs.. 15.6%, P = 0.94).
Patients of Black ethnicity are at higher risk of limb loss after a femoropopliteal bypass procedure. Further research is needed to identify the causes of this discrepancy.
先前的研究主要来自美国,报告称少数民族人群下肢旁路手术的结果较差。来自欧洲少数民族人群的全国性数据有限。本研究旨在调查英格兰少数民族人群下肢旁路手术的结果。
我们查询了“医院病例统计”数据库,使用 ICD-10 代码识别 2006 年 1 月 1 日至 2015 年 12 月 31 日期间英格兰 NHS 医院所有股-腘旁路手术病例。每例患者均随访 2 年以观察后续事件。主要结局为死亡率和主要腿部截肢。患者根据黑人、亚洲人和白人种族进行广泛分类。使用卡方检验比较各民族,并用人数最多的白人群体作为参考类别计算优势比(OR)。
在所检查的 10 年期间,记录了 20825 例股-腘旁路手术(黑人 250 例、亚洲人 167 例、白人 20408 例)。30 天和 2 年死亡率分别为 2.8%和 16.8%,种族间无显著差异。与白人相比,黑人患者肢体丧失的风险更高(23.2%比 15.6%,OR=1.63,95%置信区间 1.21-2.19,P<0.01)。亚洲人与白人的截肢率无显著差异(16.2%比 15.6%,P=0.94)。
黑人患者股-腘旁路手术后肢体丧失的风险较高。需要进一步研究以确定这种差异的原因。