Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Centre, Training and Research Hospital, Istanbul, Turkey.
Department of Cardiology, Istanbul Training and Research Hospital, Istanbul, Turkey.
Vascular. 2021 Aug;29(4):550-555. doi: 10.1177/17085381211012562. Epub 2021 May 6.
Contrast-induced acute kidney injury (CI-AKI) is a life-threatening complication that leads to comorbidities and prolonged hospital stay lengths in the setting of peripheral interventions. The presence of some CI-AKI risk factors has already been investigated. In this study, we evaluated the predictors of CI-AKI after carotid artery stenting.
A total of 389 patients with 50% to 99% carotid artery stenosis who underwent carotid artery stenting were included in this study. Patients were grouped according to CI-AKI status.
CI-AKI developed in 26 (6.6%) patients. Age, baseline creatinine level, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were higher and estimated glomerular filtration rate, haemoglobin and lymphocyte count were lower in CI-AKI patients. In the multivariate regression analysis, the neutrophil-to-lymphocyte ratio triggered a 1.39- to 2.63-fold increase in the risk of CI-AKI onset ( < 0.001).
The neutrophil-to-lymphocyte ratio may be a significant predictor of CI-AKI in patients with carotid artery stenting and higher neutrophil-to-lymphocyte ratio values may be independently associated with CI-AKI.
对比剂诱导的急性肾损伤（CI-AKI）是一种危及生命的并发症，在外周介入治疗中可导致合并症和延长住院时间。已经研究了一些 CI-AKI 的危险因素。在这项研究中，我们评估了颈动脉支架置入术后 CI-AKI 的预测因素。
本研究共纳入 389 例颈动脉狭窄 50%-99%的患者，行颈动脉支架置入术。根据 CI-AKI 情况将患者分组。
26 例（6.6%）患者发生 CI-AKI。CI-AKI 患者的年龄、基线肌酐水平、中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值较高，而估算肾小球滤过率、血红蛋白和淋巴细胞计数较低。多变量回归分析显示，中性粒细胞与淋巴细胞比值使 CI-AKI 发病风险增加 1.39 至 2.63 倍（ < 0.001）。
中性粒细胞与淋巴细胞比值可能是颈动脉支架置入术后 CI-AKI 的重要预测因素，较高的中性粒细胞与淋巴细胞比值可能与 CI-AKI 独立相关。
