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肝移植术后格林-巴利综合征

Guillain-Barre Syndrome in Orthotopic Liver Transplant Recipient.

机构信息

From the Department of General Surgery, Post Graduate institute of Medical Education & Research, Chandigarh, India.

出版信息

Exp Clin Transplant. 2021 Nov;19(11):1238-1240. doi: 10.6002/ect.2020.0286. Epub 2021 May 6.

Abstract

Guillain-Barre syndrome is an acute immune-mediated demyelinating, polyneuropathy, which is usually provoked by a preceding infection. Guillain-Barre syndrome lies within the spectrum of disimmune neuropathies and usually occurs in immunocompromised patients because it is theoretically contradictory. Guillain-Barre syndrome in liver transplant recipients has been rarely reported. Here, we present a case of a patient who had undergone a deceased donor liver transplant and who developed symptoms of Guillain-Barre syndrome in the posttransplant period. We postulated that reactivation of varicella-zoster virus in our patient triggered the autoimmune-related peripheral neuropathy leading to Guillain-Barre syndrome; another etiology for this complication may be autoimmune hepatitis, as also shown in our patient.

摘要

格林-巴利综合征是一种急性免疫介导的脱髓鞘性多发性神经病,通常由先前的感染引发。格林-巴利综合征属于免疫性神经病谱,通常发生在免疫功能低下的患者中,因为这在理论上是矛盾的。肝移植受者中的格林-巴利综合征很少见报道。在这里,我们报告了一例接受过已故供体肝移植的患者,该患者在移植后出现了格林-巴利综合征的症状。我们推测,我们患者体内水痘-带状疱疹病毒的再激活引发了导致格林-巴利综合征的自身免疫相关周围神经病;这种并发症的另一个病因可能是自身免疫性肝炎,我们的患者也有这种情况。

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