Department of Ultrasound Diagnosis, The Second Xiangya Hospital of Central South University, 139 Renmin Road (M), Changsha, 410,011, China.
Department of Ultrasound Diagnosis, The Third People Hospital of Yongzhou, Yongzhou, China.
Cardiovasc Ultrasound. 2021 May 5;19(1):18. doi: 10.1186/s12947-021-00247-0.
The objective of this study was to determine fetal foramen ovale blood flow utilizing pulsed Doppler combined with spatiotemporal image correlation.
A cross-sectional study was performed in 440 normal fetuses between 20 and 40 weeks of gestation. In order to calculate foramen ovale blood flow, the foramen ovale flow velocity-time integral was obtained by pulsed Doppler ultrasonography, and the foramen ovale area was measured by using spatiotemporal image correlation rendering mode. Foramen ovale blood flow was calculated as the product of the foramen ovale area and the velocity-time integral.
Gestational age-specific reference ranges are given for the absolute blood flow (ml/min) of foramen ovale, showing an exponential increase from 20 to 30 weeks of gestation, and a flat growth trend during the last trimester, while the weight-indexed flow (ml/min/kg) of foramen ovale decreased significantly. The median weight-indexed foramen ovale blood flow was 320.82 ml/min/kg (mean 319.1 ml/min/kg; SD 106.33 ml/min/kg).
The reference range for fetal foramen ovale blood flow was determined from 20 to 40 weeks of gestation. The present data show that the volume of foramen ovale blood flow might have a limited capacity to increase during the last trimester.
本研究旨在利用脉冲多普勒结合时空相关成像技术来测量胎儿卵圆孔血流。
对 20-40 孕周的 440 例正常胎儿进行了横断面研究。为了计算卵圆孔血流，通过脉冲多普勒超声获得卵圆孔血流速度时间积分，并用时空相关成像渲染模式测量卵圆孔面积。卵圆孔血流通过卵圆孔面积与速度时间积分的乘积来计算。
给出了卵圆孔绝对血流量（ml/min）的特定胎龄参考范围，显示从 20 周到 30 周呈指数增长，而在最后三个月呈平稳增长趋势，而卵圆孔的体重指数血流量（ml/min/kg）显著下降。卵圆孔的中位体重指数血流量为 320.82ml/min/kg（均值 319.1ml/min/kg；标准差 106.33ml/min/kg）。
确定了从 20 周到 40 周胎儿卵圆孔血流的参考范围。本研究数据表明，在最后三个月，卵圆孔血流的体积可能增加有限。
