一种制造线粒体嵴的 PERKy 方法。
A PERKy way to make mitochondrial cristae.
机构信息
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
出版信息
Trends Endocrinol Metab. 2021 Jul;32(7):417-419. doi: 10.1016/j.tem.2021.04.003. Epub 2021 May 3.
PERK protein, that is canonically associated with the response to endoplasmic reticulum stress, may be acquiring a new role as a regulator of the growth of mitochondrial cristae. This role is pertinent not only to the recruitment of brown adipose tissue thermogenic capacity but probably also to directing cristae formation in highly metabolically active organs such as the heart.
PERK 蛋白，与内质网应激反应相关的蛋白，可能获得了一个新的角色，作为调节线粒体嵴生长的调控因子。这一作用不仅与棕色脂肪组织产热能力的募集有关，而且可能与指导心脏等高度代谢活跃的器官中的嵴形成有关。
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