Department of Medicine, Allegheny General Hospital, Pittsburgh, PA, U.S.A.;
Department of Medicine, Allegheny General Hospital, Pittsburgh, PA, U.S.A.
Anticancer Res. 2021 May;41(5):2485-2488. doi: 10.21873/anticanres.15025.
BACKGROUND/AIM: Cutaneous manifestations of disease are exceedingly rare and commonly overlooked in clinical practice. Allergies or contact dermatitis, autoimmune disease or skin cancer are the most common conditions typically associated with skin lesions. Rarely, cutaneous lesions may be the first sign of internal malignancy, or even resemble recurrent disease in those with history of cancer.
Herein, we report a case of an otherwise healthy male who presented to his primary care provider (PCP) with a skin lesion misdiagnosed as a furuncle, which eventually led to diagnosis of metastatic esophageal cancer. The patient was a 64-year-old male, presenting with a fungating lesion on the tip of his nose which was biopsied, confirming adenocarcinoma likely from a gastrointestinal source. Staging imaging showed extensive lung, liver, and boney metastatic disease. He was initially treated with chemotherapy and trastuzumab.
Cutaneous lesions are a rare presenting sign of malignancy, but rapidly growing lesions should be evaluated for possible metastatic disease.
背景/目的：疾病的皮肤表现极为罕见，在临床实践中常被忽视。过敏或接触性皮炎、自身免疫性疾病或皮肤癌是最常见的与皮肤损伤相关的疾病。很少见的是，皮肤损伤可能是内部恶性肿瘤的首发表现，甚至在有癌症病史的患者中，这些损伤可能类似于复发性疾病。
在此，我们报告了一例无其他疾病的男性患者，他因皮肤损伤就诊于初级保健医生（PCP），该损伤被误诊为疖，最终导致转移性食管癌的诊断。患者为 64 岁男性，表现为鼻尖的外生样病变，该病变活检证实为腺癌，可能来自胃肠道。分期影像学检查显示广泛的肺、肝和骨转移疾病。他最初接受化疗和曲妥珠单抗治疗。
皮肤损伤是恶性肿瘤罕见的表现征象，但快速生长的病变应评估是否存在转移性疾病。
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