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中国西部地区 2 型糖尿病患者血糖控制的预测因素:一项多中心横断面研究。

Predictors of Glycemic Control among Patients with Type 2 Diabetes in Western China: A Multi-center Cross Sectional Study.

机构信息

The Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi'an Jiaotong University.

The Center for Drug Safety and Policy Research, Xi'an Jiaotong University.

出版信息

Biol Pharm Bull. 2021;44(5):620-626. doi: 10.1248/bpb.b20-00898.

DOI:10.1248/bpb.b20-00898
PMID:33952818
Abstract

The prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly in China. Glycemic control is vital in this patient population. We designed a cross-sectional questionnaire to investigate glycemic control and associated factors in T2DM patients in Western China. The survey included patients' medical history, blood glucose status, and therapeutic medications, as well as demographic data. The Chi-square test, Fisher's exact test, and logistic regression were performed to analyze the data. The STROBE checklist was used to check the procedure. Among 510 T2DM patients included in this study, 47.5% of them had blood glucose control within the normal range, defined as glycated hemoglobin A1c (HbA1c) ≤7% or fasting plasma glucose (FPG) <7.0 mmol/L. The mean age of participants was 60.58 ± 11.20 years, with a male to female ratio of 1.02 : 1. Glycemic control was significantly associated with region (p < 0.001), comorbidities (p < 0.001), monitoring frequency (p = 0.002), treatment with insulin (p = 0.003), and medication compliance (p < 0.001). Logistic regression analysis showed that unsuccessful glycemic control was significantly related to wealthier residence (p < 0.001), more comorbidities (p = 0.017), monitoring frequency (p = 0.003), and medication incompliance (p < 0.001). These results suggested that the level of glycemic control among T2DM patients in Western China was poor. It is necessary to carry out health management and nursing of diabetic patients from community, family and patients jointly.

摘要

中国 2 型糖尿病(T2DM)的患病率正在迅速上升。在这一患者群体中,血糖控制至关重要。我们设计了一项横断面问卷调查,以调查中国西部 T2DM 患者的血糖控制情况及其相关因素。该调查包括患者的病史、血糖状况和治疗药物以及人口统计学数据。采用卡方检验、Fisher 确切检验和逻辑回归分析数据。采用 STROBE 清单检查程序。本研究共纳入 510 例 T2DM 患者,其中 47.5%的患者血糖控制在正常范围内,定义为糖化血红蛋白 A1c(HbA1c)≤7%或空腹血糖(FPG)<7.0mmol/L。参与者的平均年龄为 60.58±11.20 岁,男女比例为 1.02:1。血糖控制与地区(p<0.001)、合并症(p<0.001)、监测频率(p=0.002)、胰岛素治疗(p=0.003)和药物依从性(p<0.001)显著相关。Logistic 回归分析显示,血糖控制不佳与居住地较富裕(p<0.001)、合并症较多(p=0.017)、监测频率(p=0.003)和药物不依从(p<0.001)显著相关。这些结果表明,中国西部 T2DM 患者的血糖控制水平较差。有必要共同开展社区、家庭和患者三方的糖尿病患者健康管理和护理。

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