Lipson A, Masters H, O'Halloran M, Thompson S, Coveney J, Yu J
Metabolic Clinic, Children's Hospital, Camperdown, New South Wales, Australia.
Aust Paediatr J. 1988 Apr;24(2):128-31. doi: 10.1111/j.1440-1754.1988.tb00304.x.
The selenium status of children with phenylketonuria on a synthetic low phenylalanine diet was assessed. Correlation between blood selenium and red cell glutathione peroxidase was unsatisfactory (r = 0.65) due to the poor discrimination of red cell glutathione peroxidase with a low selenium diet. No symptoms of deficiency were observed. Supplementation with 50 micrograms per week of selenium as brewers yeast tablets over a period of 6 months significantly increased the blood selenium of the phenylketonuric children. Plasma Vitamin E levels were within normal limits. The supplementation effectively doubled their selenium intake to 15-17 micrograms per day, which is probably sufficient for this group with an adequate Vitamin E status, though considerably lower than the recommended minimum intake of 50 micrograms per day.
对采用合成低苯丙氨酸饮食的苯丙酮尿症患儿的硒状况进行了评估。由于低硒饮食对红细胞谷胱甘肽过氧化物酶的区分能力较差，血硒与红细胞谷胱甘肽过氧化物酶之间的相关性并不理想（r = 0.65）。未观察到缺乏症状。在6个月的时间里，每周补充50微克作为啤酒酵母片的硒，显著提高了苯丙酮尿症患儿的血硒水平。血浆维生素E水平在正常范围内。这种补充有效地使他们的硒摄入量增加了一倍，达到每天15 - 17微克，对于该组维生素E状况良好的患儿来说可能足够了，尽管远低于建议的每日最低摄入量50微克。
