血硒浓度与谷胱甘肽过氧化物酶活性。
Blood selenium concentrations and glutathione peroxidase activity.
作者信息
Lloyd B, Robson E, Smith I, Clayton B E
机构信息
University Unit of Chemical Pathology and Human Metabolism, Southampton General Hospital.
出版信息
Arch Dis Child. 1989 Mar;64(3):352-6. doi: 10.1136/adc.64.3.352.
Selenium concentrations in children and teenagers without a metabolic disorder eating normal diets (group 1), and young patients with classical phenylketonuria and milder forms of hyperphenylalaninaemia being treated with a diet low in natural protein (group 2) were investigated. There was a strong correlation between blood selenium concentration and age in children in group 1 up to 10 years of age. Blood selenium concentrations and glutathione peroxidase activities were significantly lower in the patients who were receiving diets containing reduced amounts of natural protein, and the differences were more than would be expected for age. When the concentrations of selenium in blood from groups 1 and 2 were compared with glutathione peroxidase activity, a strong association was found when blood selenium concentrations were below 1.26 mumol/l. Reduction in glutathione peroxidase activity may be harmful in the long term, and the addition of selenium to therapeutic diets is recommended.
对饮食正常、无代谢紊乱的儿童和青少年（第1组），以及正在接受低天然蛋白饮食治疗的经典型苯丙酮尿症和轻度高苯丙氨酸血症的年轻患者（第2组）的硒浓度进行了研究。在10岁以下的第1组儿童中，血硒浓度与年龄之间存在很强的相关性。接受天然蛋白含量降低饮食的患者，其血硒浓度和谷胱甘肽过氧化物酶活性显著较低，且差异超过了按年龄预期的范围。当将第1组和第2组的血硒浓度与谷胱甘肽过氧化物酶活性进行比较时，发现血硒浓度低于1.26μmol/L时存在很强的关联。从长远来看，谷胱甘肽过氧化物酶活性降低可能有害，建议在治疗性饮食中添加硒。
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