Soheili Masoud, Karimian Mohammad, Hamidi Gholamali, Salami Mahmoud
Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran.
Iran J Basic Med Sci. 2021 Feb;24(2):123-135. doi: 10.22038/IJBMS.2020.50536.11512.
One of the most frequent forms of dementia in neurological disorders is Alzheimer's disease (AD). It is a chronic neurodegenerative disease characterized by impaired learning and memory. Pathological symptoms as extracellular amyloid-beta (Aβ) plaques and intracellular accumulation of neurofibrillary tangles occur in AD. Due to the aging of the population and increased prevalence of AD, discovery of new therapeutic agents with the highest effectiveness and fewer side effect seems to be necessary. Numerous synthetic medicines such as tacrine, donepezil, galantamine, rivastigmine, memantine, glutathione, ascorbic acid, ubiquinone, ibuprofen, and ladostigil are routinely used for reduction of the symptoms and prevention of disease progression. Nowadays, herbal medicines have attracted popular attention for numerous beneficial effects with little side effects. , and have been widely used for relief of symptoms of some neurological disorders. This paper reviews the therapeutic effects of phytomedicines with prominent effects against various factors implicated in the emergence and progression of AD.
神经疾病中最常见的痴呆形式之一是阿尔茨海默病（AD）。它是一种慢性神经退行性疾病，其特征是学习和记忆受损。AD会出现细胞外β淀粉样蛋白（Aβ）斑块和细胞内神经原纤维缠结等病理症状。由于人口老龄化以及AD患病率的增加，似乎有必要发现疗效最佳且副作用较少的新型治疗药物。许多合成药物，如他克林、多奈哌齐、加兰他敏、卡巴拉汀、美金刚、谷胱甘肽、抗坏血酸、泛醌、布洛芬和拉多司替，通常用于减轻症状和预防疾病进展。如今，草药因其具有诸多有益效果且副作用小而受到广泛关注。 以及 已被广泛用于缓解某些神经疾病的症状。本文综述了对AD发生和进展所涉及的各种因素具有显著作用的植物药的治疗效果。
