阿扑吗啡诱导的体温过低在乙醇戒断期间会加剧。

Apomorphine-induced hypothermia increases during ethanol withdrawal.

作者信息

Gonzalez L P, Colbern D L, Czachura J F

机构信息

Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73190.

出版信息

Alcohol. 1988 Mar-Apr;5(2):107-9. doi: 10.1016/0741-8329(88)90005-5.

DOI:10.1016/0741-8329(88)90005-5

PMID:3395457

Abstract

Changes in several measures of dopamine function have been observed following acute or chronic ethanol exposure. The present study examined the effects of chronic ethanol exposure on the hypothermia following acute administration of the dopamine agonist apomorphine. Animals withdrawn from chronic ethanol exposure showed a significantly greater decrease in body temperature following apomorphine than did ethanol-naive controls, suggesting an increase in sensitivity to dopaminergic stimulation during ethanol withdrawal.

摘要

在急性或慢性乙醇暴露后，已观察到多巴胺功能的若干指标发生变化。本研究检测了慢性乙醇暴露对急性给予多巴胺激动剂阿扑吗啡后体温过低的影响。与未接触乙醇的对照组相比，从慢性乙醇暴露中撤药的动物在给予阿扑吗啡后体温下降幅度明显更大，这表明在乙醇戒断期间对多巴胺能刺激的敏感性增加。