Clinical, Translational & Experimental Surgery Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
University Research Institute of Maternal & Child Health & Precision Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Eur J Clin Invest. 2021 Sep;51(9):e13578. doi: 10.1111/eci.13578. Epub 2021 May 25.
The polycystic ovary syndrome (PCOS) has genetic, epigenetic, metabolic and reproductive aspects, while its complex pathophysiology has not been conclusively deciphered.
The goal of this research was to screen the gene/gene products associated with PCOS and to predict any possible interactions with the highest possible fidelity.
STRING v10.5 database and a confidence level of 0.7 were used.
A highly interconnected network of 48 nodes was created, where insulin (INS) appears to be the major hub. INS upstream and downstream defects were analysed and revealed that only the kisspeptin- and glucagon-coding genes were upstream of INS.
A metabolic dominance was inferred and discussed herein with its implications in puberty, obesity, infertility and cardiovascular function. This study, thus, may contribute to the resolution of a scientific conflict between the USA and EU definitions of the syndrome and/or provide a new P4 medicine approach.
多囊卵巢综合征（PCOS）具有遗传、表观遗传、代谢和生殖等方面的特征，但其复杂的病理生理学尚未被明确破解。
本研究旨在筛选与 PCOS 相关的基因/基因产物，并以尽可能高的保真度预测任何可能的相互作用。
使用 STRING v10.5 数据库和置信度为 0.7。
创建了一个高度相互关联的 48 个节点网络，其中胰岛素（INS）似乎是主要枢纽。分析了 INS 的上下游缺陷，结果表明只有 kisspeptin 和胰高血糖素编码基因位于 INS 的上游。
推断出一种代谢优势，并在此讨论其对青春期、肥胖、不孕和心血管功能的影响。因此，这项研究可能有助于解决美国和欧盟对该综合征定义之间的科学冲突，并/或提供一种新的 P4 药物方法。
