Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Department of Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.
Clin Cardiol. 2021 Jun;44(6):833-838. doi: 10.1002/clc.23612. Epub 2021 May 6.
Premature ventricular contractions (PVCs) may increase during pregnancy, however, few studies have evaluated the relationship between PVCs and the pregnant outcomes.
PVCs may increase the adverse fetal/neonatal outcomes in pregnant women.
Six thousand one hundred and forty-eight pregnant women were prospectively enrolled in our center between 2017 and 2019 in the study. The average PVC burden was determined by calculating the number of PVCs in total beats. Those who had a PVC burden >0.5% were divided into two groups based on the presence or absence of adverse fetal or neonatal events. The adverse outcomes were compared between the groups to assess the impact of PVCs on pregnancy.
A total of 103 (1.68%) women with a PVC burden >0.5% were recorded. Among them, 17 adverse events (12 cases) were documented, which was significantly higher than that among women without PVCs (11.65% vs. 2.93%, p < .01). The median PVC burden among pregnant women with PVCs was 2.84% (1.02%-6.1%). Furthermore, compared with that of the women without adverse events, the median PVC burden of women with adverse fetal or neonatal outcomes was significantly higher (9.02% vs. 2.30%, p < .01). Multivariate logistic regression analysis demonstrated that not the LVEF, heart rate and bigeminy, but only the PVC burden was associated with adverse fetal or neonatal outcomes among pregnant women with PVCs (OR: 1.34, 95% CI [1.11-1.61], p < .01).
Frequent PVCs have adverse effects on pregnancy, and the PVC burden might be an important factor associated with adverse fetal and neonatal outcomes among pregnant women with PVCs.
室性期前收缩（PVCs）在怀孕期间可能会增加，但是，很少有研究评估 PVCs 与妊娠结局之间的关系。
PVCs 可能会增加孕妇不良胎儿/新生儿结局的风险。
在 2017 年至 2019 年期间，我们中心前瞻性地招募了 6148 名孕妇参与这项研究。通过计算总心搏中的 PVC 数量来确定 PVC 负荷平均值。根据是否存在不良胎儿或新生儿事件，将 PVC 负荷>0.5%的患者分为两组。比较两组之间的不良结局，以评估 PVCs 对妊娠的影响。
共记录到 103 例（1.68%）PVC 负荷>0.5%的女性。其中，有 17 例（12 例）不良事件发生，明显高于无 PVC 的女性（11.65%比 2.93%，p<0.01）。有 PVC 的孕妇的 PVC 负荷中位数为 2.84%（1.02%-6.1%）。此外，与无不良事件的孕妇相比，有不良胎儿或新生儿结局的孕妇的 PVC 负荷中位数明显更高（9.02%比 2.30%，p<0.01）。多变量逻辑回归分析表明，只有 PVC 负荷与有 PVC 的孕妇的不良胎儿或新生儿结局相关，而不是 LVEF、心率和二联律（OR：1.34，95%CI[1.11-1.61]，p<0.01）。
频发 PVCs 对妊娠有不良影响，而 PVC 负荷可能是有 PVC 的孕妇不良胎儿和新生儿结局的重要相关因素。
