Department of Otorhinolaryngology-Head and Neck Surgery, Puerta de Hierro University Hospital, Madrid, Spain.
Autonomous University of Madrid, Madrid, Spain.
Head Neck. 2021 Aug;43(8):2477-2487. doi: 10.1002/hed.26725. Epub 2021 May 6.
Validated biomarkers in head and neck squamous cell carcinoma (HNSCC) are scarce.
We retrospectively analyzed 62 patients with HNSCC treated with radiotherapy +/- concurrent chemotherapy. Pretreatment metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were measured in a F-FDG positron emission tomography using a liver dependent standardized uptake value threshold. Cox regression analyses were performed to find associations with disease-free survival (DFS) and overall survival (OS).
High values of MTV (>37 ml) were independently associated with a worse DFS (hazard ratio [HR] = 3.45; 95% confidence interval [CI], 1.52-7.84) and OS (HR = 3.27; 95% CI, 1.41-7.57). Similar results were found for high values of TLG (>247 g) for DFS (HR = 3.32; 95% CI, 1.44-7.65) and OS (HR = 3.42; 95% CI, 1.45-8.07).
MTV and TLG can be considered as independent prognostic factors for DFS and OS in patients with HNSCC. Considering how easily obtainable they are, they may be useful for predicting clinical outcomes in these patients.
头颈部鳞状细胞癌（HNSCC）中有效的生物标志物稀缺。
我们回顾性分析了 62 例接受放疗 +/- 同期化疗的 HNSCC 患者。使用基于肝脏的标准化摄取值阈值，在 F-FDG 正电子发射断层扫描中测量治疗前代谢肿瘤体积（MTV）和总病变糖酵解（TLG）。Cox 回归分析用于寻找与无病生存（DFS）和总生存（OS）相关的因素。
高 MTV 值（>37ml）与较差的 DFS（风险比[HR] = 3.45；95%置信区间[CI]，1.52-7.84）和 OS（HR = 3.27；95% CI，1.41-7.57）独立相关。TLG 高值（>247g）也与 DFS（HR = 3.32；95% CI，1.44-7.65）和 OS（HR = 3.42；95% CI，1.45-8.07）相关。
MTV 和 TLG 可作为 HNSCC 患者 DFS 和 OS 的独立预后因素。考虑到它们很容易获得，它们可能有助于预测这些患者的临床结局。
