提高头颈部癌症肿瘤分期的价值：代谢参数作为预后因素的作用。

Adding value to tumor staging in head and neck cancer: The role of metabolic parameters as prognostic factors.

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Puerta de Hierro University Hospital, Madrid, Spain.

Autonomous University of Madrid, Madrid, Spain.

出版信息

Head Neck. 2021 Aug;43(8):2477-2487. doi: 10.1002/hed.26725. Epub 2021 May 6.

DOI:10.1002/hed.26725

PMID:33955080

Abstract

BACKGROUND

Validated biomarkers in head and neck squamous cell carcinoma (HNSCC) are scarce.

METHODS

We retrospectively analyzed 62 patients with HNSCC treated with radiotherapy +/- concurrent chemotherapy. Pretreatment metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were measured in a F-FDG positron emission tomography using a liver dependent standardized uptake value threshold. Cox regression analyses were performed to find associations with disease-free survival (DFS) and overall survival (OS).

RESULTS

High values of MTV (>37 ml) were independently associated with a worse DFS (hazard ratio [HR] = 3.45; 95% confidence interval [CI], 1.52-7.84) and OS (HR = 3.27; 95% CI, 1.41-7.57). Similar results were found for high values of TLG (>247 g) for DFS (HR = 3.32; 95% CI, 1.44-7.65) and OS (HR = 3.42; 95% CI, 1.45-8.07).

CONCLUSIONS

MTV and TLG can be considered as independent prognostic factors for DFS and OS in patients with HNSCC. Considering how easily obtainable they are, they may be useful for predicting clinical outcomes in these patients.

摘要

背景

头颈部鳞状细胞癌（HNSCC）中有效的生物标志物稀缺。

方法

我们回顾性分析了 62 例接受放疗 +/- 同期化疗的 HNSCC 患者。使用基于肝脏的标准化摄取值阈值，在 F-FDG 正电子发射断层扫描中测量治疗前代谢肿瘤体积（MTV）和总病变糖酵解（TLG）。Cox 回归分析用于寻找与无病生存（DFS）和总生存（OS）相关的因素。

结果

高 MTV 值（>37ml）与较差的 DFS（风险比[HR] = 3.45；95%置信区间[CI]，1.52-7.84）和 OS（HR = 3.27；95% CI，1.41-7.57）独立相关。TLG 高值（>247g）也与 DFS（HR = 3.32；95% CI，1.44-7.65）和 OS（HR = 3.42；95% CI，1.45-8.07）相关。