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GO-BEYOND:土耳其一项关于戈利木单抗在中轴型脊柱关节炎和类风湿关节炎患者中持续性的真实世界研究。

GO-BEYOND: a real-world study of persistence of golimumab in patients with axial spondyloarthritis and rheumatoid arthritis in Turkey.

机构信息

Izmir Katip Celebi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Izmir, Turkey.

Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey.

出版信息

Immunotherapy. 2021 Jul;13(10):841-850. doi: 10.2217/imt-2020-0296. Epub 2021 May 6.

Abstract

To evaluate the retention rate of golimumab (GLM) in patients with rheumatoid arthritis (RA) and axial spondyloarthritis (ax-SpA). Patients had received/were receiving GLM as their first or second biological drug for at least 3 months. We recorded demographic and clinical data, data on drug continuation and disease activity. Patients were classified as biologic-naive and biologic-experienced. The study included 60 RA and 269 ax-SpA patients. At month 24, the retention rates were 67.2 and 57.1% (biologic-naive and biologic-experienced RA) and 74.8 and 80.4% (anti-TNF-naive and -experienced ax-SpA). No significant differences in retention were observed between the biologic-naive and -experienced groups for either disease. The results of this study confirm the effectiveness of GLM in the treatment of RA and axSpA with good retention rates at 2 years in a real-world setting in Turkey.

摘要

评估类风湿关节炎(RA)和中轴型脊柱关节炎(ax-SpA)患者接受戈利木单抗(GLM)治疗的保留率。患者至少接受过/正在接受 GLM 作为他们的第一种或第二种生物药物治疗,至少 3 个月。我们记录了人口统计学和临床数据、药物持续使用和疾病活动的数据。患者分为生物初治和生物经治。本研究纳入了 60 例 RA 和 269 例 ax-SpA 患者。在第 24 个月,保留率分别为 67.2%和 57.1%(生物初治和生物经治 RA)以及 74.8%和 80.4%(抗 TNF 初治和经治 ax-SpA)。两种疾病的生物初治和经治组之间均未观察到保留率的显著差异。本研究结果证实了 GLM 在治疗 RA 和 axSpA 方面的有效性,在土耳其真实环境下,2 年的保留率良好。

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