Reilly C S, Merrell J, Wood A J, Koshakji R P, Wood M
Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee.
Br J Anaesth. 1988 Jun;60(7):791-6. doi: 10.1093/bja/60.7.791.
The disposition of propranolol was studied, using dual-route administration, in two groups of six dogs. Each dog was studied on three consecutive days: day 1 awake, day 2 during anaesthesia, and day 3, 24 h after anaesthesia. Anaesthesia was with isoflurane 2.0 MAC (in oxygen) in one group and with a fentanyl-nitrous oxide-atracurium regimen in the other group. In the group receiving fentanyl, anaesthesia caused a significant decrease (63%) in intrinsic clearance from the day 1 value (P less than 0.05) and a 45% decrease in systemic clearance (P less than 0.05). Hepatic plasma flow decreased by 27% (ns). A similar pattern was found with isoflurane: intrinsic clearance decreased by 53% (P less than 0.05) and systemic clearance by 40% (P less than 0.05). Hepatic plasma flow decreased by 40% (ns). In both groups, the values 24 h after anaesthesia were not significantly different from those obtained on day 1. Anaesthesia with either fentanyl-nitrous oxide-atracurium or isoflurane has a marked, but short-lasting effect on the disposition of propranolol, in part as a result of a decrease in intrinsic clearance.
采用双途径给药法，在两组各6只犬中研究了普萘洛尔的处置情况。每只犬连续3天接受研究：第1天清醒状态，第2天麻醉状态，第3天在麻醉后24小时。一组犬用2.0MAC异氟烷（在氧气中）麻醉，另一组犬采用芬太尼-氧化亚氮-阿曲库铵方案麻醉。在接受芬太尼的组中，麻醉使内在清除率较第1天的值显著降低（63%）（P<0.05），全身清除率降低45%（P<0.05）。肝血浆流量下降27%（无统计学意义）。异氟烷麻醉时也发现了类似模式：内在清除率降低53%（P<0.05），全身清除率降低40%（P<0.05）。肝血浆流量下降40%（无统计学意义）。在两组中，麻醉后24小时的值与第1天获得的值无显著差异。芬太尼-氧化亚氮-阿曲库铵或异氟烷麻醉对普萘洛尔的处置均有显著但短暂的影响，部分原因是内在清除率降低。
