Riccabona G
Wien Klin Wochenschr. 1977 Dec 23;89(24):805-12.
Nuclear medicine offers the possibility of quantitative (clearance techniques) and semiquantitative (sequential gamma-camera studies) renal function studies, which can be done with minimal discomfort to the patient at a low radiation exposure. Scintillation cameras with data-storing and computer systems are used after administration of labelled chelates (99mTc-DTPA, 111In-DTPA, 51Cr-EDTA) and labelled contrast media excreted by glomerular filtration (131I-Iothalamate, 131I-Hypaque) and after injection of 131I-ortho-iodo-hippuric acid (131I-Hippuran). The use of 99mTc gives further information on regional renal perfusion, which can be supplemented by exact data after injection of 133Xe into the renal artery. The described methods have proved to be valuable in the diagnosis of renal artery stenoses, in the follow-up of inflammatory kidney disease, in the assessment of hypertensive patients, in the differentiation of renal lesions with destruction of parenchyma, in the follow-up of urinary tract obstruction and in the follow-up of patients with transplanted kidneys over many years. The correlation of nuclear medicine data with chemical and clinical parameters is excellent. Studies of renal function by radionuclides have, thus, acquired an important role in the evaluation and follow-up of nephrological and urological patients.
核医学提供了进行定量（清除技术）和半定量（连续γ相机研究）肾功能研究的可能性，这些研究可以在对患者造成最小不适且辐射暴露较低的情况下完成。在给予通过肾小球滤过排泄的标记螯合物（99m锝-二乙三胺五乙酸、111铟-二乙三胺五乙酸、51铬-乙二胺四乙酸）和标记造影剂（131碘-异泛影酸钠、131碘-泛影葡胺）后，以及注射131碘-邻碘马尿酸（131碘-马尿酸）后，使用带有数据存储和计算机系统的闪烁相机。使用99m锝可进一步获得有关局部肾灌注的信息，在肾动脉注射133氙后可通过精确数据进行补充。所描述的方法已被证明在肾动脉狭窄的诊断、炎症性肾脏疾病的随访、高血压患者的评估、实质破坏的肾病变的鉴别、尿路梗阻的随访以及肾移植患者多年的随访中具有重要价值。核医学数据与化学和临床参数的相关性非常好。因此，放射性核素肾功能研究在肾脏病学和泌尿外科学患者的评估和随访中发挥了重要作用。
