Department of Ophthalmology, Region Västra Götaland, Skaraborg Hospital, Skövde, Sweden.
Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Acta Ophthalmol. 2022 Feb;100(1):e115-e121. doi: 10.1111/aos.14868. Epub 2021 May 6.
To investigate visual perception problems (VPPs), health-related quality of life (HRQoL) and vision-related quality of life (VRQoL) in young adults with foetal alcohol spectrum disorders (FASD) and to compare the results with healthy controls.
Thirty young adults with FASD (13 female; mean age 23 years) and 29 controls (20 female; mean age 25 years) participated. Five areas of VPPs were assessed by a structured history-taking. In the FASD group, VPPs were investigated both in childhood (mean age 8 years) and in early adulthood in a prospective follow-up. Health-related quality of life (HRQoL) was investigated with the Pediatric Quality of Life Inventory™ (PedsQL) and VRQoL with the 25-item Visual Function Questionnaire (VFQ-25).
Visual perception problems (VPPs) in at least one area were reported by 16/30 FASD participants (53%) and 1/29 controls (3%) (p = 0.0001, Fisher's exact test), with a similar rate in the same individuals in childhood as in early adulthood (8/27 and 15/27, respectively p = 0.09, McNemar's test). PedsQL total score was lower in the FASD group (n = 20; median: 83; 95% confidence interval (CI) 76-88) compared with controls (n = 29; median: 91; 95% CI 90-95; p = 0.0001, Mann-Whitney U-test). VFQ-25 subscale general vision indicated lower VRQoL in the young adults with FASD (n = 19; median: 80; 95% CI 80-100) compared with controls (n = 29; median: 100; 95% CI 100-100; p = 0.003).
Young adults with FASD in the present study had more VPPs and worse VRQoL and HRQoL than healthy controls. In the FASD group, VPPs were reported in childhood as well as in early adulthood.
研究胎儿酒精谱系障碍（FASD）年轻患者的视觉感知问题（VPP）、健康相关生活质量（HRQoL）和视觉相关生活质量（VRQoL），并将结果与健康对照组进行比较。
30 名 FASD 患者（13 名女性；平均年龄 23 岁）和 29 名对照组（20 名女性；平均年龄 25 岁）参加了研究。通过结构化病史采集评估了 5 个 VPP 领域。在 FASD 组中，在儿童期（平均年龄 8 岁）和前瞻性随访的成年早期均对 VPP 进行了研究。采用儿童生活质量问卷（PedsQL）评估健康相关生活质量（HRQoL），采用 25 项视觉功能问卷（VFQ-25）评估 VRQoL。
30 名 FASD 患者中有 16/30（53%）和 29 名对照组中有 1/29（3%）报告存在至少一个领域的 VPP（p=0.0001，Fisher 确切检验），在同一患者的儿童期和成年早期的发生率相似（8/27 和 15/27，分别为 p=0.09，McNemar 检验）。FASD 组（n=20）的 PedsQL 总分（中位数：83；95%置信区间（CI）76-88）低于对照组（n=29；中位数：91；95%CI 90-95；p=0.0001，Mann-Whitney U 检验）。FASD 组（n=19）的 VFQ-25 一般视力子量表的 VRQoL 较对照组（n=29）低（中位数：80；95%CI 80-100）（p=0.003）。
本研究中的 FASD 年轻患者的 VPP 更多，VRQoL 和 HRQoL 更差。在 FASD 组中，在儿童期和成年早期都报告了 VPP。
